Effects of Catecholamine-Infusions and Hypoxia on Pulmonary Blood Volume and Extravascular Lung Water Content in Cats

1975 ◽  
Vol 95 (1) ◽  
pp. 34-40 ◽  
Author(s):  
P. Aarseth ◽  
J. Karlsen ◽  
G. Bø
Keyword(s):  
Water Content ◽  
Blood Volume ◽  
Extravascular Lung Water ◽  
Lung Water ◽  
Pulmonary Blood Volume ◽  
Lung Water Content

Radiographic lung density assessed by computed tomography is associated with extravascular lung water content

2010 ◽  
Vol 54 (8) ◽  
pp. 1018-1026 ◽  
Author(s):  
V. V. KUZKOV ◽  
E. V. SUBOROV ◽  
M. Y. KIROV ◽  
K. WAERHAUG ◽  
R. MORTENSEN ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Water Content ◽  
Extravascular Lung Water ◽  
Lung Water ◽  
Lung Density ◽  
Lung Water Content

Effect of different levels of positive end-expiratory pressure on lung water content

1982 ◽  
Vol 53 (1) ◽  
pp. 9-15 ◽  
Author(s):  
J. A. Russell ◽  
J. Hoeffel ◽  
J. F. Murray
Keyword(s):  
Water Content ◽  
Dry Weight ◽  
Water Volume ◽  
Positive End Expiratory Pressure ◽  
Lung Water ◽  
Pulmonary Blood Volume ◽  
The Difference ◽  
Lung Water Content ◽  
Different Levels

To compare the effects of 2-, 5-, and 10-cmH2O positive end-expiratory pressure (PEEP) on pulmonary extravascular water volume (PEWV), pulmonary blood volume (PBV), pulmonary dry weight (PDW), and distensibility, we separately ventilated perfused dogs' lungs in situ and produced pulmonary edema with oleic acid (0.06 ml/kg). Three groups were studied: I, PEEP, 5 cmH2O in both lung; II, PEEP, 2 cmH2O in one lung and 10 cmH2O in the other; and III, PEEP, same as II, but the chest was rotated to compensate for differences in heights. The PEWV and distensibility were less (P less than 0.05) in lungs exposed to 10-cmH2O than to either 2- or 5-cmH2O PEEP. After chest rotation, the difference between 10- and 2-cmH2O PEEP on PEWV was eliminated but that on distensibility was not. We conclude that 10-cmH2O PEEP 1) decreased water content because of lung volume-induced effects on intravascular hydrostatic pressure and 2) improved distensibility by recruitment of alveoli, irrespective of PEWV.

Effect of dehydration on interstitial pressures in the isolated dog lung

1989 ◽  
Vol 67 (2) ◽  
pp. 839-845 ◽  
Author(s):  
M. R. Glucksberg ◽  
J. Bhattacharya
Keyword(s):  
Blood Flow ◽  
Water Content ◽  
Extravascular Lung Water ◽  
Base Line ◽  
Inflation Pressure ◽  
Lung Water ◽  
Lung Expansion ◽  
Regional Lung ◽  
Lung Water Content

We have determined the effect of dehydration on regional lung interstitial pressures. We stopped blood flow in the isolated blood-perfused lobe of dog lung at vascular pressure of approximately 4 cmH2O. Then we recorded interstitial pressures by micropuncture at alveolar junctions (Pjct), in perimicrovascular adventitia (Padv), and at the hilum (Phil). After base-line measurements, we ventilated the lobes with dry gas to decrease extravascular lung water content by 14 +/- 5%. In one group (n = 10), at constant inflation pressure of 7 cmH2O, Pjct was 0.2 +/- 0.8 and Padv was -1.5 +/- 0.6 cmH2O. After dehydration the pressures fell to -5.0 +/- 1.0 and -5.3 +/- 1.3 cmH2O, respectively (P less than 0.01), and the junction-to-advential gradient (Pjct-Padv) was abolished. In a second group (n = 6) a combination of dehydration and lung expansion with inflation pressure of 15 cmH2O further decreased Pjct and Padv to -7.3 +/- 0.7 and -7.1 +/- 0.7 cmH2O, respectively. Phil followed changes in Padv. Interstitial compliance was 0.6 at the junctions, 0.8 in adventitia, and 0.9 ml.cmH2O-1.100 g-1 wet lung at the hilum. We conclude, that perialveolar interstitial pressures may provide an important mechanism for prevention of lung dehydration.

Clearance of liquid from lungs of newborn rabbits

1980 ◽  
Vol 49 (2) ◽  
pp. 171-177 ◽  
Author(s):  
R. D. Bland ◽  
D. D. McMillan ◽  
M. A. Bressack ◽  
L. Dong
Keyword(s):  
Cesarean Section ◽  
Liquid Nitrogen ◽  
Blood Volume ◽  
Lung Tissue ◽  
Extravascular Lung Water ◽  
Frozen Sections ◽  
Lung Water ◽  
Pulmonary Blood Volume ◽  
Pulmonary Vessels ◽  
Cuff Size

Apparent inconsistencies in the results of previous studies led us to reexamine the process by which fluid leaves the lungs of newborn rabbits after birth. We measured pulmonary blood volume, extravascular lung water, and the size of perivascular cuffs of fluid in frozen sections of lung obtained from 166 full-term rabbits (31 days gestation) born vaginally or by cesarean section. We killed the rabbits by giving them barbiturate intraperitoneally and immersing them in liquid nitrogen before they breathed or at randomly predetermined intervals from 5 min to 24 h after birth. We found that a) pulmonary blood volume of both groups of rabbits increased soon after birth, b) extravascular lung water per gram of dry lung tissue was greater at birth in rabbits born by cesarean section than in those born vaginally, c) extravascular lung water did not begin to decrease in either group of animals until 30-60 min postnatally, after which it decreased progressively for 24 h, and d) the rate of fluid clearance and pattern of puddling around pulmonary vessels was similar in both groups of rabbits, with maximal perivascular cuffs 30 min after birth, followed by diminution of cuff size as the lungs shed water.

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