Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

2020 ◽  
Vol 25 (9) ◽  
pp. 930-944 ◽  
Author(s):  
Yanmei Chen ◽  
Wolfram Weckwerth
Keyword(s):  
Mass Spectrometry ◽  
Membrane Protein ◽  
Signaling Networks ◽  
Protein Signaling ◽  
Protein Signaling Networks

scholarly journals Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance

Proteomes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 19
Author(s):  
Giusj Monia Pugliese ◽  
Sara Latini ◽  
Giorgia Massacci ◽  
Livia Perfetto ◽  
Francesca Sacco
Keyword(s):  
Mass Spectrometry ◽  
Drug Resistance ◽  
Myeloid Leukemia ◽  
Molecular Mechanisms ◽  
Systems Approach ◽  
Genetic Alterations ◽  
Signaling Networks ◽  
Protein Signaling ◽  
Flt3 Mutations ◽  
Protein Signaling Networks

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial goal of biomedical research. Given the complexity and intricacy of protein signaling networks, deciphering the molecular basis of FLT3-driven drug resistance requires a systems approach. Here we discuss how the recent advances in mass spectrometry (MS)-based (phospho) proteomics and multiparametric analysis accompanied by emerging computational approaches offer a platform to obtain and systematically analyze cell-specific signaling networks and to identify new potential therapeutic targets.

scholarly journals Revisiting the Training of Logic Models of Protein Signaling Networks with ASP

2012 ◽  
pp. 342-361 ◽  
Author(s):  
Santiago Videla ◽  
Carito Guziolowski ◽  
Federica Eduati ◽  
Sven Thiele ◽  
Niels Grabe ◽  
...  
Keyword(s):  
Signaling Networks ◽  
Protein Signaling ◽  
Logic Models ◽  
Protein Signaling Networks

scholarly journals Image-based spatiotemporal causality inference for protein signaling networks

2017 ◽  
Vol 33 (14) ◽  
pp. i217-i224
Author(s):  
Xiongtao Ruan ◽  
Christoph Wülfing ◽  
Robert F Murphy
Keyword(s):  
Signaling Networks ◽  
Protein Signaling ◽  
Causality Inference ◽  
Protein Signaling Networks

scholarly journals CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms

2012 ◽  
Vol 6 (1) ◽  
pp. 133 ◽  
Author(s):  
Camille Terfve ◽  
Thomas Cokelaer ◽  
David Henriques ◽  
Aidan MacNamara ◽  
Emanuel Goncalves ◽  
...  
Keyword(s):  
Signaling Networks ◽  
Protein Signaling ◽  
Protein Signaling Networks

scholarly journals Modeling of Protein Signaling Networks in Clinical Proteomics

2005 ◽  
Vol 70 (0) ◽  
pp. 517-524 ◽  
Author(s):  
D.H. GEHO ◽  
E.F. PETRICOIN ◽  
L.A. LIOTTA ◽  
R.P. ARAUJO
Keyword(s):  
Clinical Proteomics ◽  
Signaling Networks ◽  
Protein Signaling ◽  
Protein Signaling Networks
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