Comparison of Endothelial Nitric Oxide Synthase and Endothelin-1 Levels in Kidneys Removed From Living Pigs After Cardiac Arrest and Brain Death

2014 ◽  
Vol 46 (8) ◽  
pp. 2542-2544 ◽  
Author(s):  
G. Oczkowicz ◽  
A. Caban ◽  
G. Budziński ◽  
A. Suszka-Świtek ◽  
B. Dolińska ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiac Arrest ◽  
Nitric Oxide Synthase ◽  
Brain Death ◽  
Endothelial Nitric Oxide Synthase ◽  
Endothelin 1 ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Expression of Endothelial Nitric Oxide Synthase and Endothelin-1 in Skin Tissue from Amputated Limbs of Patients with Complex Regional Pain Syndrome

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
J. George Groeneweg ◽  
Claudia Heijmans Antonissen ◽  
Frank J. P. M. Huygen ◽  
Freek J. Zijlstra
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Nitric Oxide Synthase ◽  
Complex Regional Pain Syndrome ◽  
Endothelial Nitric Oxide Synthase ◽  
Pain Syndrome ◽  
Skin Tissue ◽  
Endothelin 1 ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Background and Objectives. Impaired microcirculation during the chronic stage of complex regional pain syndrome (CRPS) is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. Endothelial dysfunction is suggested to be the main cause of diminished blood flow. The aim of this study was to examine the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1(ET-1) relative to vascular density represented by the endothelial marker CD31-immunoreactivity in the skin tissue of patients with chronic CRPS.Methods. We performed immunohistochemical staining on sections of skin specimens obtained from the amputated limbs (one arm and one leg) of two patients with CRPS.Results. In comparison to proximal specimens we found an increased number of migrated endothelial cells as well as an increase of eNOS activity in distal dermis specimens.Conclusions. We found indications that endothelial dysfunction plays a role in chronic CRPS.

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