Application of Amniotic Stem Cells on an Acellular Dermal Matrix Scaffold in a Burned Patient: A Case Report

The development of skin tissue engineering provides a noninvasive method for skin restoration. Unfortunately, the lack of a vascular plexus leads to greater time for vascularization compared with native skin autografts and contributes to graft failure. Our purpose was to construct tissue-engineered skin with VEGF- modified human bone marrow mesenchymal stem cells (hMSCs) as well as acellular dermal matrix(ADM) in vitro , Thus by increased vascular endothelial growth factor expression, which could prospectively improve vascularization of tissue-engineered skin for wound healing applications. To reach this aim, hMSCs were isolated and cultured with density gradient centrifugation combined with attachment culture method in vitro. Liposome- mediated gene transfer was used to generate a population of hMSCs overexpressing the gene encoding VEGF165. Then VEGF- modified hMSCs were seeded onto the surface of ADM. The experimental results showed that ADM we prepared has good compatibility with MSCs, the cells in ADM grew and proliferated well in vitro and the tissue - engineered skin with VEGF- modified hMSCs and ADM has been successfully constructed.

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The effect of allogenic human Wharton's jelly stem cells seeded onto acellular dermal matrix in healing of rat burn wounds

Journal of Cosmetic Dermatology ◽

10.1111/jocd.13109 ◽

2019 ◽

Vol 19 (4) ◽

pp. 995-1001 ◽

Cited By ~ 2

Author(s):

Mehra Nazempour ◽

Davood Mehrabani ◽

Rouhollah Mehdinavaz‐Aghdam ◽

Seyedeh‐Sara Hashemi ◽

Amin Derakhshanfar ◽

...

Keyword(s):

Stem Cells ◽

Acellular Dermal Matrix ◽

Wharton’S Jelly ◽

Dermal Matrix ◽

Burn Wounds ◽

Wharton's Jelly ◽

Acellular Dermal

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Treatment of Exposed Bone With Acellular Dermal Matrix in a Smoker Patient After Dental Implant Surgery: A Case Report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00221 ◽

2019 ◽

Vol 46 (3) ◽

pp. 245-249

Author(s):

Levent Cigerim

Keyword(s):

Case Report ◽

Dental Implant ◽

Acellular Dermal Matrix ◽

Gingival Recession ◽

Dermal Matrix ◽

Attached Gingiva ◽

Exposed Bone ◽

Dermal Cells ◽

Dental Implant Surgery ◽

Acellular Dermal

Acellular dermal matrix is a biocompatible material derived from human and animal connective tissue. This material is created by a chemical process in which all epidermal and dermal cells are removed but the bioactive dermal matrix is left intact. The bioactive dermal matrix has the capability to promote natural revascularization and cell repopulation and to undergo tissue remodeling as it contains elastin, collagen, bioactive proteins, and blood vessel channels. Recently, ADM materials have successfully been used as grafts in numerous surgical procedures to increase the size of the attached gingiva surrounding the teeth and implants, to fill in gingival recession defects to enhance root coverage, to manage soft-tissue ridge deformities, and to repair oronasal fistulae. The aim of this case report is to evaluate the use of the acellular dermal matrix in a 45-year-old patient with an area of exposed bone after the placement of a dental implant.

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Immediate Implantation With Ridge Augmentation Using Acellular Dermal Matrix and Deproteinized Bovine Bone: A Case Report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-10-00063 ◽

2011 ◽

Vol 37 (6) ◽

pp. 717-721 ◽

Cited By ~ 1

Author(s):

Jun-Beom Park

Keyword(s):

Case Report ◽

Treatment Time ◽

Acellular Dermal Matrix ◽

Bovine Bone ◽

Dermal Matrix ◽

Ridge Augmentation ◽

Immediate Implant ◽

Challenging Situation ◽

Immediate Implantation ◽

Acellular Dermal

Immediate implant placement combined with hard and soft tissue grafting has been suggested because it may preclude dramatic postextraction bone loss and may decrease overall discomfort with reduction in the number of surgeries and in treatment time. In this case report, the acellular dermal matrix was used as a membrane for immediate implantation via a bone augmentation procedure in an esthetically challenging situation. The author suggests that this surgical technique provides the clinician with an option for an immediate implant therapy when primary closure is not intended. Additional randomized controlled trials conducted over long periods are necessary to establish whether this procedure offers long-term benefit to patients.

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