Hyperbaric Oxygen Therapy in Rats Attenuates Ischemia-reperfusion Testicular Injury Through Blockade of Oxidative Stress, Suppression of Inflammation, and Reduction of Nitric Oxide Formation

Urology ◽  
2013 ◽  
Vol 82 (2) ◽  
pp. 489.e9-489.e15 ◽  
Author(s):  
Yu Zhang ◽  
Yan Lv ◽  
Yan-Juan Liu ◽  
Chen Yang ◽  
Hui-Jun Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Ischemia Reperfusion ◽  
Oxide Formation ◽  
Nitric Oxide Formation ◽  
Testicular Injury

scholarly journals Oxidative stress is fundamental to hyperbaric oxygen therapy

2009 ◽  
Vol 106 (3) ◽  
pp. 988-995 ◽  
Author(s):  
Stephen R. Thom
Keyword(s):  
Oxidative Stress ◽  
Signal Transduction ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Species ◽  
Controlled Clinical Trials ◽  
Therapeutic Mechanisms ◽  
Cell Signal Transduction

The goal of this review is to outline advances addressing the role that reactive species of oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will be organized around major categories of problems or processes where controlled clinical trials have demonstrated clinical efficacy for hyperbaric oxygen therapy. Reactive species are now recognized to play a major role in cell signal transduction cascades, and the discussion will focus on how hyperbaric oxygen acts through these pathways to mediate wound healing and ameliorate postischemic and inflammatory injuries.

scholarly journals Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress

2018 ◽  
Vol 33 (1) ◽  
pp. 1501-1505 ◽  
Author(s):  
Gerardo Bosco ◽  
Giuliano Vezzani ◽  
Simona Mrakic Sposta ◽  
Alex Rizzato ◽  
Garrett Enten ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
And Oxidative Stress

Fasciotomy Closure Using Simultaneous Vacuum-Assisted Closure and Hyperbaric Oxygen

2007 ◽  
Vol 73 (3) ◽  
pp. 261-266
Author(s):  
Dennis E. Weiland
Keyword(s):  
Vascular Disease ◽  
Compartment Syndrome ◽  
Hyperbaric Oxygen ◽  
Skin Graft ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Ischemia Reperfusion ◽  
Trauma Patients ◽  
Vacuum Assisted Closure ◽  
Early Closure

Fasciotomies performed for compartment syndrome and ischemic vascular disease often requires closure in 2 to 4 weeks by skin graft. This leaves the patient with an unsightly scar and a limb with reduced strength. The use of vacuum-assisted closure (VAC) and hyperbaric oxygen therapy (HBOT) quickly reduce the edema and permit earlier closure with adjacent skin. A study of three trauma patients with compartment syndrome, fasciotomies, and the use of the VAC and HBOT to close the fasciotomy wounds with adjacent skin is presented. The pathophysiology of compartment syndrome and ischemia-reperfusion syndrome is discussed. These patients had closure of the fasciotomy wounds in 3 to 18 days. The simultaneous use of HBOT and VAC accelerates the reduction of edema in a synergistic fashion, permitting early closure of fasciotomy wounds.

scholarly journals Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

2011 ◽  
Vol 26 (6) ◽  
pp. 463-469 ◽  
Author(s):  
Rosemary Aparecida Furlan Daniel ◽  
Vinícius Kannen Cardoso ◽  
Emanuel Góis Jr ◽  
Rogério Serafim Parra ◽  
Sérgio Britto Garcia ◽  
...  
Keyword(s):  
Cell Viability ◽  
Reperfusion Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Intestinal Ischemia ◽  
Oxygen Therapy ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Exact Nature ◽  
Intestinal Tissue

PURPOSE: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT) has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R) injury response in intestinal model of I/R injury. METHODS: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA). Microvascular density and apoptosis were evaluated by immunohistochemistry. RESULTS: The results indicate that HBOT treatment pre- and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression. CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways.

Hyperbaric Oxygen Therapy Induces Kidney Protection in an Ischemia/Reperfusion Model in Rats

2012 ◽  
Vol 44 (8) ◽  
pp. 2333-2336 ◽  
Author(s):  
R.J. Ramalho ◽  
P.S.T. de Oliveira ◽  
R.C. Cavaglieri ◽  
C. Silva ◽  
P.R.B. Medeiros ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Ischemia Reperfusion ◽  
Kidney Protection
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