Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model

2006 ◽  
Vol 24 (2) ◽  
pp. 141-151 ◽  
Author(s):  
Benjamin K. Canales ◽  
Yingming Li ◽  
Melissa G. Thompson ◽  
Joseph M. Gleason ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
Cancer Model ◽  
Androgen Independent ◽  
Prostate Cancer Model

scholarly journals Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model

2017 ◽  
Vol Volume 12 ◽  
pp. 6357-6364 ◽  
Author(s):  
Celine Mirjolet ◽  
Julien Boudon ◽  
Alexis Loiseau ◽  
Sandy Chevrier ◽  
Romain Boidot ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Titanate Nanotubes ◽  
Cancer Model ◽  
Androgen Independent ◽  
Prostate Cancer Model

scholarly journals Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model

Oncotarget ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 3338-3352 ◽  
Author(s):  
Chenrui Li ◽  
Zhijun Wang ◽  
Qian Wang ◽  
Rebecca Lucinda Ka Yan Ho ◽  
Ying Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Model ◽  
Prostate Cancer Model

Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model

The Prostate ◽  
2006 ◽  
Vol 67 (1) ◽  
pp. 83-106 ◽  
Author(s):  
Sharon D. Morgenbesser ◽  
Rajashree P. McLaren ◽  
Brenda Richards ◽  
Mindy Zhang ◽  
Viatcheslav R. Akmaev ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Metastatic Tumor ◽  
Genetically Engineered ◽  
Cancer Model ◽  
Mouse Prostate ◽  
Androgen Independent ◽  
Prostate Cancer Model

scholarly journals Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
S. Inder ◽  
M. Bates ◽  
N. Ni Labhrai ◽  
N. McDermott ◽  
J. Schneider ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Expression Profiles ◽  
Protein Profiling ◽  
Cancer Model ◽  
Protein Levels ◽  
Notch 3 ◽  
Molecular Radiation ◽  
Protein Expression Profiles ◽  
Prostate Cancer Model

AbstractThe exact biological mechanism governing the radioresistant phenotype of prostate tumours at a high risk of recurrence despite the delivery of advanced radiotherapy protocols remains unclear. This study analysed the protein expression profiles of a previously generated isogenic 22Rv1 prostate cancer model of radioresistance using DigiWest multiplex protein profiling for a selection of 90 signalling proteins. Comparative analysis of the profiles identified a substantial change in the expression of 43 proteins. Differential PARP-1, AR, p53, Notch-3 and YB-1 protein levels were independently validated using Western Blotting. Pharmacological targeting of these proteins was associated with a mild but significant radiosensitisation effect at 4Gy. This study supports the clinical relevance of isogenic in vitro models of radioresistance and clarifies the molecular radiation response of prostate cancer cells.

Molecular Therapy with Recombinant p53 Adenovirus in an Androgen-Independent, Metastatic Human Prostate Cancer Model

1996 ◽  
Vol 7 (14) ◽  
pp. 1683-1691 ◽  
Author(s):  
Song-Chu Ko ◽  
Akinobu Gotoh ◽  
George N. Thalmann ◽  
Haiyen E. Zhau ◽  
Dennis A. Johnston ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Therapy ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Model ◽  
Androgen Independent ◽  
Prostate Cancer Model

NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study

2014 ◽  
Vol 110 (2) ◽  
pp. 348-354 ◽  
Author(s):  
Shuraila F. Zerp ◽  
Conchita Vens ◽  
Ben Floot ◽  
Marcel Verheij ◽  
Baukelien van Triest
Keyword(s):  
Prostate Cancer ◽  
In Vivo Study ◽  
Cancer Model ◽  
Nad Depletion ◽  
Prostate Cancer Model
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