Contemporary analysis of the effect of marital status on survival in upper tract urothelial carcinoma patients treated with radical nephroureterectomy: A population-based study

2021 ◽  
Author(s):  
Claudia Collà Ruvolo ◽  
Luigi Nocera ◽  
Franziska L. Stolzenbach ◽  
Mike Wenzel ◽  
Christoph Würnschimmel ◽  
...  
Keyword(s):  
Marital Status ◽  
Urothelial Carcinoma ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Population Based Study ◽  
Upper Tract

scholarly journals External validation of the pathological nodal staging score in upper tract urothelial carcinoma: A population-based study

2017 ◽  
Vol 35 (1) ◽  
pp. 33.e21-33.e26 ◽  
Author(s):  
Evanguelos Xylinas ◽  
Luis Kluth ◽  
Malte Rieken ◽  
Morgan Rouprêt ◽  
Bashir Al Hussein Al Awamlh ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
External Validation ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Nodal Staging ◽  
Population Based Study ◽  
Upper Tract

Operative management in patients with upper tract urothelial carcinoma in Iceland: a population-based study

2021 ◽  
pp. 1-6
Author(s):  
Oddur Björnsson ◽  
Eiríkur Jónsson ◽  
Eiríkur Orri Guðmundsson ◽  
Valur Þór Marteinsson ◽  
Sigfús Þór Nikulásson ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Operative Management ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Population Based Study ◽  
Upper Tract

scholarly journals Marital status impacts survival in patients with upper tract urothelial carcinoma: a population-based, propensity-matched study

2020 ◽  
Vol 9 (4) ◽  
pp. 1611-1629 ◽  
Author(s):  
Keyi Wang ◽  
Weipu Mao ◽  
Heng Shi ◽  
Guangchun Wang ◽  
Lei Yin ◽  
...  
Keyword(s):  
Marital Status ◽  
Urothelial Carcinoma ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract ◽  
Matched Study

Nephroureterectomy and segmental ureterectomy in the treatment of invasive upper tract urothelial carcinoma: A population-based study of 2299 patients

2009 ◽  
Vol 45 (18) ◽  
pp. 3291-3297 ◽  
Author(s):  
Giovanni Lughezzani ◽  
Claudio Jeldres ◽  
Hendrik Isbarn ◽  
Maxine Sun ◽  
Shahrokh F. Shariat ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Population Based Study ◽  
Upper Tract ◽  
Segmental Ureterectomy

Developing a nomogram for predicting intravesical recurrence after radical nephroureterectomy: a retrospective cohort study of mainland Chinese patients

2021 ◽  
Author(s):  
Shicong Lai ◽  
Xingbo Long ◽  
Pengjie Wu ◽  
Jianyong Liu ◽  
Samuel Seery ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Cox Regression ◽  
Upper Tract Urothelial Carcinoma ◽  
Chinese Patients ◽  
Clinicopathological Parameters ◽  
Radical Nephroureterectomy ◽  
Ki 67 ◽  
Data Set ◽  
Mainland Chinese ◽  
Upper Tract

Abstract Objective To evaluate the role of Ki-67 in predicting subsequent intravesical recurrence following radical nephroureterectomy and to develop a predictive nomogram for upper tract urothelial carcinoma patients. Methods This retrospective analysis involved 489 upper tract urothelial carcinoma patients who underwent radical nephroureterectomy with bladder cuff excision. The data set was randomly split into a training cohort of 293 patients and a validation cohort of 196 patients. Immunohistochemical analysis was used to assess the immunoreactivity of the biomarker Ki-67 in the tumor tissues. A multivariable Cox regression model was utilized to identify independent intravesical recurrence predictors after radical nephroureterectomy before constructing a nomographic model. Predictive accuracy was quantified using time-dependent receiver operating characteristic curve. Decision curve analysis was performed to evaluate the clinical benefit of models. Results With a median follow-up of 54 months, intravesical recurrence developed in 28.2% of this sample (n = 137). Tumor location, multifocality, pathological T stage, surgical approach, bladder cancer history and Ki-67 expression levels were independently associated with intravesical recurrence (all P < 0.05). The full model, which intercalated Ki-67 with traditional clinicopathological parameters, outperformed both the basic model and Xylinas’ model in terms of discriminative capacity (all P < 0.05). Decision-making analysis suggests that the more comprehensive model can also improve patients’ net benefit. Conclusions This new model, which intercalates the Ki-67 biomarker with traditional clinicopathological factors, appears to be more sensitive than nomograms previously tested across mainland Chinese populations. The findings suggest that Ki-67 could be useful for determining risk-stratified surveillance protocols following radical nephroureterectomy and in generating an individualized strategy based around intravesical recurrence predictions.

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