Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant hepatitis E virus-like particles

Vaccine ◽  
2004 ◽  
Vol 22 (3-4) ◽  
pp. 370-377 ◽  
Author(s):  
Tian-Cheng Li ◽  
Yuriko Suzaki ◽  
Yasushi Ami ◽  
Tapankumar N Dhole ◽  
Tatsuo Miyamura ◽  
...  
Keyword(s):  
Oral Administration ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Cynomolgus Monkeys ◽  
Virus Like Particles

scholarly journals Chimeric Recombinant Hepatitis E Virus-like Particles as an Oral Vaccine Vehicle Presenting Foreign Epitopes

Virology ◽  
2002 ◽  
Vol 293 (2) ◽  
pp. 273-280 ◽  
Author(s):  
Masahiro Niikura ◽  
Shiki Takamura ◽  
Gisen Kim ◽  
Satoru Kawai ◽  
Masayuki Saijo ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Oral Vaccine ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles

Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin®

Vaccine ◽  
2014 ◽  
Vol 32 (32) ◽  
pp. 4039-4050 ◽  
Author(s):  
Xiao Zhang ◽  
Minxi Wei ◽  
Huirong Pan ◽  
Zhijie Lin ◽  
Kaihang Wang ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles ◽  
Robust Manufacturing ◽  
Comprehensive Characterization

scholarly journals Recombinant Hepatitis E virus like particles can function as RNA nanocarriers

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Subrat Kumar Panda ◽  
Neeraj Kapur ◽  
Daizy Paliwal ◽  
Hemlata Durgapal
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles

Recombinant Hepatitis E virus like particles can function as RNA nanocarriers

nano Online ◽  
2016 ◽  
Author(s):  
Subrat Kumar Panda ◽  
Neeraj Kapur ◽  
Daizy Paliwal ◽  
Hemlata Durgapal
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles

scholarly journals Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 64
Author(s):  
Gergana Zahmanova ◽  
Milena Mazalovska ◽  
Katerina Takova ◽  
Valentina Toneva ◽  
Ivan Minkov ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nicotiana Benthamiana ◽  
Hepatitis E Virus ◽  
Chimeric Protein ◽  
Hepatitis E ◽  
Core Antigen ◽  
Efficient Production ◽  
Virus Like Particles ◽  
B Virus

The core antigen of hepatitis B virus (HBcAg) is capable of self-assembly into virus-like particles (VLPs) when expressed in a number of heterologous systems. Such VLPs are potential carriers of foreign antigenic sequences for vaccine design. In this study, we evaluated the production of chimeric HBcAg VLPs presenting a foreign epitope on their surface, the 551–607 amino acids (aa) immunological epitope of the ORF2 capsid protein of hepatitis E virus. A chimeric construct was made by the insertion of 56 aa into the immunodominant loop of the HBcAg. The sequences encoding the chimera were inserted into the pEAQ-HT vector and infiltrated into Nicotiana benthamiana leaves. The plant-expressed chimeric HBcHEV ORF2 551–607 protein was recognized by an anti-HBcAg mAb and anti-HEV IgG positive swine serum. Electron microscopy showed that plant-produced chimeric protein spontaneously assembled into “knobbly” ~34 nm diameter VLPs. This study shows that HBcAg is a promising carrier platform for the neutralizing epitopes of hepatitis E virus (HEV) and the chimeric HBcAg/HEV VLPs could be a candidate for a bivalent vaccine.

scholarly journals Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

2014 ◽  
Vol 15 (4) ◽  
pp. 575 ◽  
Author(s):  
Young-Jo Song ◽  
Woo-Jung Park ◽  
Seul-Kee Lee ◽  
Joong-Bok Lee ◽  
Seung-Yong Park ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Γ ◽  
Virus Like Particles ◽  
Swine Hepatitis
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