Augmented humoral and cellular immune responses of a hepatitis B DNA vaccine encoding HBsAg by protein boosting

Vaccine ◽  
2005 ◽  
Vol 23 (14) ◽  
pp. 1649-1656 ◽  
Author(s):  
He Xiao-wen ◽  
Sun Shu-han ◽  
Hu Zhen-lin ◽  
Li Jun ◽  
Jiang Lei ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Humoral and cellular immune responses to modified hepatitis B plasmid DNA vaccine in mice

2016 ◽  
Vol 15 (4) ◽  
pp. 687
Author(s):  
Mounir M Salem-Bekhit ◽  
Mohamed Osman Gad El Rab ◽  
Mahmoud M Tawfick ◽  
Mohammad Raish ◽  
Mohamed Dahmani Fathallah ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Plasmid Dna ◽  
Cellular Immune Responses ◽  
Plasmid Dna Vaccine ◽  
Cellular Immune

Augmented humoral and cellular immune responses to hepatitis B DNA vaccine adsorbed onto cationic microparticles

2005 ◽  
Vol 107 (2) ◽  
pp. 357-372 ◽  
Author(s):  
Xiaowen He ◽  
Lei Jiang ◽  
Fang Wang ◽  
Zhenyu Xiao ◽  
Jun Li ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals A polyvalent influenza DNA vaccine applied by needle-free intradermal delivery induces cross-reactive humoral and cellular immune responses in pigs

Vaccine ◽  
2016 ◽  
Vol 34 (32) ◽  
pp. 3634-3640 ◽  
Author(s):  
Marie Borggren ◽  
Jens Nielsen ◽  
Ingrid Karlsson ◽  
Tina S. Dalgaard ◽  
Ramona Trebbien ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Intradermal Delivery ◽  
Cellular Immune

Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses

Vaccine ◽  
2004 ◽  
Vol 22 (27-28) ◽  
pp. 3789-3796 ◽  
Author(s):  
L Jarrosson ◽  
M.N Kolopp-Sarda ◽  
P Aguilar ◽  
M.C Béné ◽  
M.L Lepori ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Immune Responses ◽  
Cellular Immune Responses ◽  
Hepatitis B Vaccines ◽  
Cellular Immune

scholarly journals Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

Vaccine ◽  
2008 ◽  
Vol 26 (49) ◽  
pp. 6225-6231 ◽  
Author(s):  
Krystle A. Lang ◽  
Jian Yan ◽  
Ruxandra Draghia-Akli ◽  
Amir Khan ◽  
David B. Weiner
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Rhesus Macaques ◽  
Hcv Genotype ◽  
Cellular Immune Responses ◽  
Genotype 1A ◽  
Cellular Immune

Antitumor Effect of a DNA Vaccine Harboring Prostate Cancer-Specific Antigen with IL-12 as an Intramolecular Adjuvant

2017 ◽  
Vol 27 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Yu Yang ◽  
Zhiqiang Shao ◽  
Jiangping Gao
Keyword(s):  
Prostate Cancer ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Dna Vaccines ◽  
Electric Pulse ◽  
Specific Antigen ◽  
Interleukin 12 ◽  
Cellular Immune Responses ◽  
Prostate Cancer Therapy ◽  
Cellular Immune

To improve the lower immune intensity of DNA vaccines, we developed a DNA vaccine based on prostate cancer-specific antigen (PSA), which has been suggested as a potential target for prostate cancer therapy, and enhanced the DNA vaccine potency using interleukin-12 (IL-12) as an intramolecular adjuvant. A series of DNA plasmids encoding human PSA, IL-12, and their conjugates was constructed and injected into female mice intramuscularly, followed by an electric pulse. The humoral and cellular immune responses after immunization were detected by ELISA and ELISPOT, respectively. To evaluate the therapeutic efficacy of these plasmids, a mouse model with a PSA-expressing tumor was constructed. Mice vaccinated with PSA-IL-12 plasmids elicited the strongest PSA-specific humoral and cellular immune responses. Furthermore, these vaccinations inhibited the growth of PSA-expressing tumors and prolonged mouse survival. These observations emphasize the potential of the IL-12 gene as an intramolecular adjuvant for DNA vaccines. Moreover, the vaccine based on PSA and IL-12 may be a promising treatment for prostate cancer.

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