Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site

Vaccine ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Michelle Rémond ◽  
Bruno Da Costa ◽  
Sabine Riffault ◽  
Satya Parida ◽  
Emmanuel Breard ◽  
...  
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Infectious Bursal Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Bursal Disease ◽  
Subviral Particles

A Highly Divergent Antigenic Site of Foot-and-Mouth Disease Virus Retains Its Immunodominance

1995 ◽  
Vol 8 (1) ◽  
pp. 11-18 ◽  
Author(s):  
B. BORREGO ◽  
J.A. CAMARERO ◽  
M.G. MATEU ◽  
E. DOMINGO
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host

Virology ◽  
1995 ◽  
Vol 206 (1) ◽  
pp. 298-306 ◽  
Author(s):  
Mauricio G. Mateu ◽  
Julio A. Camarero ◽  
Ernest Giralt ◽  
David Andreu ◽  
Esteban Domingo
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Natural Host ◽  
Direct Evaluation ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus

FEBS Letters ◽  
1993 ◽  
Vol 328 (1-2) ◽  
pp. 159-164 ◽  
Author(s):  
Julio A. Camarero ◽  
David Andreu ◽  
Jordi J. Cairó ◽  
Mauricio G. Mateu ◽  
Esteban Domingo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Foot-and-mouth disease virus epitope dominance in the antibody response of vaccinated animals

2012 ◽  
Vol 93 (3) ◽  
pp. 488-493 ◽  
Author(s):  
M. Mahapatra ◽  
P. Hamblin ◽  
D. J. Paton
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Escape Mutant ◽  
Target Species ◽  
Serotype O ◽  
Antigenic Sites ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Five neutralizing antigenic sites have been identified on the surface of serotype O foot-and-mouth disease virus (FMDV). A set of mAb neutralization-escape mutant viruses was used for the first time to evaluate the relative use of known binding sites by polyclonal antibodies from three target species: cattle, sheep and pigs. Antibodies to all five neutralizing antigenic sites were detected in all three species, with most antibodies directed against antigenic site 2, followed by antigenic site 1. In 76 % of cattle, 65 % of sheep and 58 % of pigs, most antibodies were directed against site 2. Antibodies specific to antigenic sites 3, 4 and 5 were found to be minor constituents in the sera of each of the target species. This implies that antigenic site 2 is a dominant neutralization immunogenic site in serotype O FMDV and may therefore be a good candidate for designing novel vaccines.

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