scholarly journals Rational design of novel fusion rabies glycoproteins displaying a major antigenic site of foot-and-mouth disease virus for vaccine applications

2021 ◽  
Author(s):  
Ernesto Garay ◽  
Diego Fontana ◽  
Lautaro Leschiutta ◽  
Ricardo Kratje ◽  
Claudio Prieto
Keyword(s):  
Disease Virus ◽  
Rational Design ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

A Highly Divergent Antigenic Site of Foot-and-Mouth Disease Virus Retains Its Immunodominance

1995 ◽  
Vol 8 (1) ◽  
pp. 11-18 ◽  
Author(s):  
B. BORREGO ◽  
J.A. CAMARERO ◽  
M.G. MATEU ◽  
E. DOMINGO
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Xenoepitope Substitution Avoids Deceptive Imprinting and Broadens the Immune Response to Foot-and-Mouth Disease Virus

2012 ◽  
Vol 19 (4) ◽  
pp. 461-467 ◽  
Author(s):  
Steven M. Szczepanek ◽  
Roger W. Barrette ◽  
Debra Rood ◽  
Diana Alejo ◽  
Lawrence K. Silbart
Keyword(s):  
Immune Response ◽  
B Cell ◽  
Disease Virus ◽  
Rational Design ◽  
Rna Viruses ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Decoy Epitope

ABSTRACTMany RNA viruses encode error-prone polymerases which introduce mutations into B and T cell epitopes, providing a mechanism for immunological escape. When regions of hypervariability are found within immunodominant epitopes with no known function, they are referred to as “decoy epitopes,” which often deceptively imprint the host's immune response. In this work, a decoy epitope was identified in the foot-and-mouth disease virus (FMDV) serotype O VP1 G-H loop after multiple sequence alignment of 118 isolates. A series of chimeric cyclic peptides resembling the type O G-H loop were prepared, each bearing a defined “B cell xenoepitope” from another virus in place of the native decoy epitope. These sequences were derived from porcine respiratory and reproductive syndrome virus (PRRSV), from HIV, or from a presumptively tolerogenic sequence from murine albumin and were subsequently used as immunogens in BALB/c mice. Cross-reactive antibody responses against all peptides were compared to a wild-type peptide and ovalbumin (OVA). A broadened antibody response was generated in animals inoculated with the PRRSV chimeric peptide, in which virus binding of serum antibodies was also observed. A B cell epitope mapping experiment did not reveal recognition of any contiguous linear epitopes, raising the possibility that the refocused response was directed to a conformational epitope. Taken together, these results indicate that xenoepitope substitution is a novel method for immune refocusing against decoy epitopes of RNA viruses such as FMDV as part of the rational design of next-generation vaccines.

A cyclic disulfide peptide reproduces in solution the main structural features of a native antigenic site of foot-and-mouth disease virus

1997 ◽  
Vol 20 (3) ◽  
pp. 209-219 ◽  
Author(s):  
Thomas Haack ◽  
Julio A. Camarero ◽  
Xavier Roig ◽  
Mauricio G. Mateu ◽  
Esteban Domingo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Structural Features ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host

Virology ◽  
1995 ◽  
Vol 206 (1) ◽  
pp. 298-306 ◽  
Author(s):  
Mauricio G. Mateu ◽  
Julio A. Camarero ◽  
Ernest Giralt ◽  
David Andreu ◽  
Esteban Domingo
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Natural Host ◽  
Direct Evaluation ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Extensive antigenic diversification of foot-and-mouth disease virus by amino acid substitutions outside the major antigenic site

1992 ◽  
Vol 73 (12) ◽  
pp. 3307-3311 ◽  
Author(s):  
D. Feigelstock ◽  
M. G. Mateu ◽  
M. E. Piccone ◽  
F. De Simone ◽  
E. Brocchi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Amino Acid Substitutions ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site

Vaccine ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Michelle Rémond ◽  
Bruno Da Costa ◽  
Sabine Riffault ◽  
Satya Parida ◽  
Emmanuel Breard ◽  
...  
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Infectious Bursal Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Bursal Disease ◽  
Subviral Particles

Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus

FEBS Letters ◽  
1993 ◽  
Vol 328 (1-2) ◽  
pp. 159-164 ◽  
Author(s):  
Julio A. Camarero ◽  
David Andreu ◽  
Jordi J. Cairó ◽  
Mauricio G. Mateu ◽  
Esteban Domingo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Antigenic Site ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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