scholarly journals Effects of Repeated Annual Inactivated Influenza Vaccination among Healthcare Personnel on Serum Hemagglutinin Inhibition Antibody Response to A/Perth/16/2009 (H3N2)-like virus during 2010-11

Vaccine ◽  
2016 ◽  
Vol 34 (7) ◽  
pp. 981-988 ◽  
Author(s):  
Mark G. Thompson ◽  
Allison Naleway ◽  
Alicia M. Fry ◽  
Sarah Ball ◽  
Sarah M. Spencer ◽  
...  
Author(s):  
Alexandria D Tricoche ◽  
Abram L Wagner ◽  
Angel Balmaseda ◽  
Nery Sanchez ◽  
Mayuri Patel ◽  
...  

Abstract Background Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. Methods This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012–2017 were categorized by symptom status. Results Antibody response was assessed using hemagglutination inhibition assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% confidence interval, 1.02–4.64). Conclusions Studies relying on serological assays may not generalize to asymptomatic infections.


2013 ◽  
Vol 34 (7) ◽  
pp. 723-729 ◽  
Author(s):  
Kayla L. Fricke ◽  
Mariella M. Gastañaduy ◽  
Renee Klos ◽  
Rodolfo E. Bégué

Objective.To describe practices for influenza vaccination of healthcare personnel (HCP) with emphasis on correlates of increased vaccination rates.Design.Survey.Participants.Volunteer sample of hospitals in Louisiana.Methods.All hospitals in Louisiana were invited to participate. A 17-item questionnaire inquired about the hospital type, patients served, characteristics of the vaccination campaign, and the resulting vaccination rate.Results.Of 254 hospitals, 153 (60%) participated and were included in the 124 responses that were received. Most programs (64%) required that HCP either receive the vaccine or sign a declination form, and the rest were exclusively voluntary (36%); no program made vaccination a condition of employment. The median vaccination rate was 67%, and the vaccination rate was higher among hospitals that were accredited by the Joint Commission; provided acute care; served children, pregnant women, oncology patients, or intensive care unit patients; required a signed declination form; or imposed consequences for unvaccinated HCP (the most common of which was to require that a mask be worn on patient contact). Hospitals that provided free vaccine, made vaccine widely available, advertised the program extensively, required a declination form, and imposed consequences had the highest vaccination rates (median, 86%; range, 81%–91%).Conclusions.The rate of influenza vaccination of HCP remains low among the hospitals surveyed. Recommended practices may not be enough to reach 90% vaccination rates unless a signed declination requirement and consequences are implemented. Wearing a mask is a strong consequence. Demanding influenza vaccination as a condition of employment was not reported as a practice by the participating hospitals.


Author(s):  
Minji Kang ◽  
Sherry Clark ◽  
Sandra Mendoza ◽  
Doramarie Arocha ◽  
James B. Cutrell ◽  
...  

2012 ◽  
Vol 33 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Jürgen Maurer ◽  
Katharine M. Harris ◽  
Carla L. Black ◽  
Gary L. Euler

Objective.To measure support for seasonal influenza vaccination requirements among US healthcare personnel (HCP) and its associations with attitudes regarding influenza and influenza vaccination and self-reported coverage by existing vaccination requirements.Design.Between lune 1 and June 30, 2010, we surveyed a sample of US HCP (n = 1,664) recruited using an existing probability-based online research panel of participants representing the US general population as a sampling frame.Setting.General community.Participants.Eligible HCP who (1) reported having worked as medical doctors, health technologists, healthcare support staff, or other health practitioners or who (2) reported having worked in hospitals, ambulatory care facilities, long-term care facilities, or other health-related settings.Methods.We analyzed support for seasonal influenza vaccination requirements for HCP using proportion estimation and multivariable probit models.Results.A total of 57.4% (95% confidence interval, 53.3%–61.5%) of US HCP agreed that HCP should be required to be vaccinated for seasonal influenza. Support for mandatory vaccination was statistically significantly higher among HCP who were subject to employer-based influenza vaccination requirements, who considered influenza to be a serious disease, and who agreed that influenza vaccine was safe and effective.Conclusions.A majority of HCP support influenza vaccination requirements. Moreover, providing HCP with information about the safety of influenza vaccination and communicating that immunization of HCP is a patient safety issue may be important for generating staff support for influenza vaccination requirements.Infect Control Hosp Epidemiol 2012;33(3):213-221


2020 ◽  
Vol 9 (1) ◽  
pp. 976-987 ◽  
Author(s):  
Na Lei ◽  
Yan Li ◽  
Qiang Sun ◽  
Jian Lu ◽  
Jianfang Zhou ◽  
...  

Vaccine ◽  
2000 ◽  
Vol 18 (26) ◽  
pp. 3040-3049 ◽  
Author(s):  
Frank P Kroon ◽  
Jaap T van Dissel ◽  
Jan C de Jong ◽  
Koos Zwinderman ◽  
Ralph van Furth

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