A novel cardiopulmonary safety pharmacology monitoring method using telemetry in cynomolgus monkeys evaluated with pharmacological modulators

2010 ◽  
Vol 62 (2) ◽  
pp. e27
Author(s):  
Simon Authier ◽  
Paul Haefner ◽  
Sebastien Fournier ◽  
Boyce Moon
Keyword(s):  
Monitoring Method ◽  
Cynomolgus Monkeys ◽  
Safety Pharmacology ◽  
Pharmacological Modulators

A cardiovascular monitoring system in conscious cynomolgus monkeys for regulatory safety pharmacology

2007 ◽  
Vol 56 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Simon Authier ◽  
Jean-Francois Tanguay ◽  
Dominique Gauvin ◽  
Rocky Di Fruscia ◽  
Sebastien Fournier ◽  
...  
Keyword(s):  
Monitoring System ◽  
Cardiovascular Monitoring ◽  
Cynomolgus Monkeys ◽  
Safety Pharmacology

Hexachlorobenzene toxicity in the monkey ovary: III. Ultrastructure induced by high (10 mg/kg) dose exposure

1991 ◽  
Vol 49 ◽  
pp. 130-131
Author(s):  
A. Singh ◽  
A. Dykeman ◽  
J. Jarrelf ◽  
D. C. Villeneuve
Keyword(s):  
Present Report ◽  
Reproductive Toxicity ◽  
Control Group ◽  
Primate Model ◽  
Human Follicular Fluid ◽  
Thin Sections ◽  
Cynomolgus Monkeys ◽  
Cacodylate Buffer ◽  
Induction Cycle ◽  
Comprehensive Study

Hexachlorobenzene (HCB), a persistent and mobile organochlorine pesticide, occurs in environment. HCB has been shown to be present in human follicular fluid. An objective of the present report, which is part of a comprehensive study on reproductive toxicity of HCB, was to determine the cytologic effects of the compound on ovarian follicles in a primate model.Materials and Methods. Eight Cynomolgus monkeys were housed under controlled conditions at Animal facility of Health and Welfare, Ottawa. Animals were orally administered gelatin capsules containing HCB mixed with glucose in daily dosages of 0.0 or 10 mg/kg b.w. for 90 days; the former was the control group. On the menstrual period following completion of dosing, the monkeys underwent an induction cycle of superovulation. At necropsy, one-half of an ovary from each animal was diced into ca. 2- to 3-mm cubed specimens that were fixed by immersion in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.3). Subsequent procedures followed to obtain thin sections that were examined in a Hitachi H-7000 electron microscope have been described earlier.

Hemodynamic effects of induced fetal anemia in cynomolgus monkeys

1998 ◽  
Vol 5 (1) ◽  
pp. 159A-159A
Author(s):  
W BLOCK ◽  
M OSULLIVAN ◽  
N SMITH ◽  
M DRAPER ◽  
C MIRABILE ◽  
...  
Keyword(s):  
Fetal Anemia ◽  
Hemodynamic Effects ◽  
Cynomolgus Monkeys
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