scholarly journals Monoclonal antibody analysis of Porcine Reproductive and Respiratory Syndrome virus epitopes associated with antibody-dependent enhancement and neutralization of virus infection

2004 ◽  
Vol 102 (3) ◽  
pp. 249-262 ◽  
Author(s):  
Sol M. Cancel-Tirado ◽  
Richard B. Evans ◽  
Kyoung-Jin Yoon
Keyword(s):  
Monoclonal Antibody ◽  
Virus Infection ◽  
Respiratory Syndrome Virus ◽  
Antibody Dependent Enhancement

scholarly journals Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection

2015 ◽  
Vol 96 (7) ◽  
pp. 1712-1722 ◽  
Author(s):  
Weihong Gu ◽  
Li Feng ◽  
Haidong Yu ◽  
Zhijun Tian ◽  
Mingming Huang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Respiratory Syndrome Virus ◽  
Antibody Dependent Enhancement

scholarly journals The potential for antibody-dependent enhancement of SARS-CoV-2 infection: Translational implications for vaccine development

2020 ◽  
pp. 1-4 ◽  
Author(s):  
Jiong Wang ◽  
Martin S. Zand
Keyword(s):  
Monoclonal Antibody ◽  
Virus Infection ◽  
Dengue Virus ◽  
Vaccine Development ◽  
Surface Proteins ◽  
Dengue Virus Infection ◽  
Antibody Dependent Enhancement ◽  
High Affinity ◽  
Viral Surface

Abstract There is an urgent need for vaccines to the 2019 coronavirus (COVID19; SARS-CoV-2). Vaccine development may not be straightforward, due to antibody-dependent enhancement (ADE). Antibodies against viral surface proteins can, in some cases, increase infection severity by ADE. This phenomenon occurs in SARS-CoV-1, MERS, HIV, Zika, and dengue virus infection and vaccination. Lack of high-affinity anti-SARS-CoV-2 IgG in children may explain the decreased severity of infection in these groups. Here, we discuss the evidence for ADE in the context of SARS-CoV-2 infection and how to address this potential translational barrier to vaccine development, convalescent plasma, and targeted monoclonal antibody therapies.

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

scholarly journals Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128292 ◽  
Author(s):  
Gang Wang ◽  
Ying Yu ◽  
Yabin Tu ◽  
Jie Tong ◽  
Yonggang Liu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Induced Apoptosis

scholarly journals Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus

2000 ◽  
Vol 76 (1-2) ◽  
pp. 125-135 ◽  
Author(s):  
M.G.M De Bruin ◽  
J.N Samsom ◽  
J.J.M Voermans ◽  
E.M.A van Rooij ◽  
Y.E De Visser ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Pseudorabies Virus ◽  
Respiratory Syndrome Virus
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