Effect of a biological response modifier on expression of CD14 receptor and tumor necrosis factor-alpha in Staphylococcus aureus-infected mammary glands at drying off

2009 ◽  
Vol 132 (2-4) ◽  
pp. 237-242 ◽  
Author(s):  
B.E. Dallard ◽  
C. Baravalle ◽  
H.H. Ortega ◽  
M. Tumini ◽  
V.R. Canavesio ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Biological Response ◽  
Mammary Glands ◽  
Biological Response Modifier ◽  
Response Modifier ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals The Extracellular Adherence Protein from Staphylococcus aureus Inhibits Neutrophil Binding to Endothelial Cells

2004 ◽  
Vol 72 (10) ◽  
pp. 6164-6167 ◽  
Author(s):  
Axana Haggar ◽  
Cecilia Ehrnfelt ◽  
Jan Holgersson ◽  
Jan-Ingmar Flock
Keyword(s):  
Staphylococcus Aureus ◽  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Neutrophil Adhesion ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Adhesion Assays

ABSTRACT Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.

scholarly journals Shedding of Tumor Necrosis Factor Receptor 1 Induced by Protein A Decreases Tumor Necrosis Factor Alpha Availability and Inflammation during Systemic Staphylococcus aureus Infection

2013 ◽  
Vol 81 (11) ◽  
pp. 4200-4207 ◽  
Author(s):  
Constanza Giai ◽  
Cintia Gonzalez ◽  
Camila Ledo ◽  
Ailin Garofalo ◽  
María Silvia Di Genaro ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Protein A ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACTStaphylococcus aureusinfections are an important public health concern due to their increasing incidence and high rates of mortality. The success ofS. aureusas a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the initial host defense against systemic staphylococcal infection has been demonstrated in experimental models and may partially explain the lack of significant benefits observed in clinical trials attempting to neutralize this cytokine in septic patients.S. aureusprotein A plays a key role in regulating inflammation through its ability to bind and signal through the TNF-α receptor 1 (TNFR1). In this study, we demonstrate thatS. aureus, via protein A-mediated signaling, induces early shedding of TNFR1, which precedes the secretion of TNF-αin vitroandin vivo. The results obtained using a protein A-deficient mutant andtnfr1−/−mice strongly suggest that the increased levels of soluble TNFR1 present during experimentalS. aureusinfection may neutralize circulating TNF-α and impair the host inflammatory response. Early shedding of TNFR1 induced by protein A may constitute a novel mechanism by whichS. aureussubverts the host immune response.

Sign in / Sign up

Export Citation Format

Share Document