scholarly journals The contribution of the immune response to enhanced colibacillosis upon preceding viral respiratory infection in broiler chicken in a dual infection model

Author(s):  
Erik A.W.S. Weerts ◽  
Mieke G.R. Matthijs ◽  
Josette Bonhof ◽  
Daphne A. van Haarlem ◽  
R. Marius Dwars ◽  
...  
2019 ◽  
Author(s):  
Andrew Becker ◽  
Gary An ◽  
Chase Cockrell

AbstractViral respiratory infections, such as influenza, result in over 1 million deaths worldwide each year. To date, there are few therapeutic interventions able to affect the course of the disease once acquired, a deficit with stark consequences that were readily evident in the current COVID-19 pandemic. We present the Cellular Immune Agent Based Model (CIABM) as a flexible framework for modeling acute viral infection and cellular immune memory development. The mechanism/rule-based nature of the CIABM allows for interrogation of the complex dynamics of the human immune system during various types of viral infections. The CIABM is an extension of a prior agent-based model of the innate immune response, incorporating additional cellular types and mediators involved in the response to viral infection. The CIABM simulates the dynamics of viral respiratory infection in terms of epithelial invasion, immune cellular population changes and cytokine measurements. Validation of the CIABM involved effectively replicating in vivo measurements of circulating mediator levels from a clinical cohort of influenza patients. The general purpose nature of the CIABM allows for both the representation of various types of known viral infections and facilitates the exploration of hypothetical, novel viral pathogens.


PEDIATRICS ◽  
2016 ◽  
Vol 137 (4) ◽  
pp. e20153555-e20153555 ◽  
Author(s):  
T. Chonmaitree ◽  
R. Trujillo ◽  
K. Jennings ◽  
P. Alvarez-Fernandez ◽  
J. A. Patel ◽  
...  

PEDIATRICS ◽  
2002 ◽  
Vol 109 (5) ◽  
pp. 826-832 ◽  
Author(s):  
B. Winther ◽  
F. G. Hayden ◽  
E. Arruda ◽  
R. Dutkowski ◽  
P. Ward ◽  
...  

Author(s):  
Ma. Eugenia ◽  
Dora Patricia ◽  
Luis Horacio ◽  
Rodolfo Ocadiz-Delgado ◽  
Carlos Cabello-Gutierrez

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