Naphthylisoquinoline alkaloids and their synthetic analogs as potent novel inhibitors against Babesia canis in vitro

2020 ◽  
Vol 283 ◽  
pp. 109177
Author(s):  
Gerhard Bringmann ◽  
Shaimaa Fayez ◽  
William Shamburger ◽  
Doris Feineis ◽  
Stanislaw Winiarczyk ◽  
...  
Keyword(s):  
Babesia Canis ◽  
Synthetic Analogs ◽  
Naphthylisoquinoline Alkaloids

Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibition

2013 ◽  
Vol 21 (17) ◽  
pp. 5188-5197 ◽  
Author(s):  
Hui Wu ◽  
Charles J. Kelley ◽  
Alejandro Pino-Figueroa ◽  
Huyen D. Vu ◽  
Timothy J. Maher
Keyword(s):  
Synthetic Analogs ◽  
Faah Inhibition

New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo

2017 ◽  
Vol 137 ◽  
pp. 11-29 ◽  
Author(s):  
Pinelopi Samara ◽  
Nikoleta Christoforidou ◽  
Christelle Lemus ◽  
Aikaterini Argyropoulou ◽  
Kyriaki Ioannou ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Synthetic Analogs

In silico evaluation and in vitro growth inhibition of Plasmodium falciparum by natural amides and synthetic analogs

2020 ◽  
Vol 119 (6) ◽  
pp. 1879-1887
Author(s):  
Minelly Azevedo da Silva ◽  
Márcia Paranho Veloso ◽  
Kassius de Souza Reis ◽  
Guilherme de Matos Passarini ◽  
Ana Paula de Azevedo dos Santos ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Growth Inhibition ◽  
In Silico ◽  
In Vitro Growth ◽  
Synthetic Analogs

Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture

1992 ◽  
Vol 14 (3) ◽  
pp. 295-305 ◽  
Author(s):  
TH. P. M. SCHETTERS ◽  
J. KLEUSKENS ◽  
N. SCHOLTES ◽  
H. J. BOS
Keyword(s):  
In Vitro Culture ◽  
Babesia Canis

scholarly journals In vitro assembly of phytochrome B apoprotein with synthetic analogs of the phytochrome chromophore

2001 ◽  
Vol 98 (6) ◽  
pp. 3612-3617 ◽  
Author(s):  
H. Hanzawa ◽  
K. Inomata ◽  
H. Kinoshita ◽  
T. Kakiuchi ◽  
K. P. Jayasundera ◽  
...  
Keyword(s):  
Phytochrome B ◽  
Synthetic Analogs ◽  
In Vitro Assembly

Vitamin D3 and Its Synthetic Analogs Inhibit the Spontaneous in Vitro Immunoglobulin Production by SLE-Derived PBMC

2001 ◽  
Vol 99 (1) ◽  
pp. 82-93 ◽  
Author(s):  
M. Linker-Israeli ◽  
E. Elstner ◽  
J.R. Klinenberg ◽  
D.J. Wallace ◽  
H.P. Koeffler
Keyword(s):  
Vitamin D3 ◽  
Immunoglobulin Production ◽  
Synthetic Analogs

In vitro antiviral activity of dehydroepiandrosterone, 17 synthetic analogs and ERK modulators against herpes simplex virus type 1

2012 ◽  
Vol 95 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Nicolás I. Torres ◽  
Viviana Castilla ◽  
Andrea C. Bruttomesso ◽  
Javier Eiras ◽  
Lydia R. Galagovsky ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Synthetic Analogs ◽  
Simplex Virus

Analysis of the culture-derived soluble Babesia canis canis antigens derived from the Polish strains of the parasites

2012 ◽  
Vol 40 (06) ◽  
pp. 399-403 ◽  
Author(s):  
A. Puchalski ◽  
M. Dec ◽  
S. Winiarczyk ◽  
L. Adaszek
Keyword(s):  
Western Blotting ◽  
Polyacrylamide Gel Electrophoresis ◽  
In Vitro Cultures ◽  
Protein Fractions ◽  
Babesia Canis ◽  
Subunit Vaccines ◽  
Molecular Weights ◽  
Starting Point ◽  
Babesia Canis Canis

Summary Objective, material and methods: The aim of this study was to analyse the protein fractions of the soluble parasitic antigen (SPA) from in vitro cultures of the native Polish strains of Babesia canis canis and to determine their immunogenicity through Western blotting using the sera of dogs vaccinated with this antigen. Results: Polyacrylamide gel electrophoresis revealed 21 protein fractions with molecular weights from 12 to 205 kDa. The most intense reaction in Western blotting was observed between the serum antibodies of the SPA-vaccinated dogs and the fraction with the molecular weight of 52 kDa. Conclusion: Detailed studies on the composition of SPA of Babesia canis canis and reactivity of its individual protein fractions can be a starting point for the development of subunit vaccines against babesiosis. Using a preparation with only some electrophoretic fractions of SPA in the production of vaccines would allow to avoid putting an unnecessary protein burden in the vaccine which could cause side effects.

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