Metal nanostructures with single molecule sensitivity in surface enhanced Raman scattering

2004 ◽  
Vol 35 (1-2) ◽  
pp. 121-129 ◽  
Author(s):  
Masayuki Futamata ◽  
Yoshihiro Maruyama ◽  
Mitsuru Ishikawa
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Surface Enhanced Raman Scattering ◽  
Metal Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Fabrication of Highly Rough Ag Nanobud Substrates and Surface-Enhanced Raman Scattering ofλ-DNA Molecules

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Chuyun Deng ◽  
Wanyun Ma ◽  
Jia-Lin Sun
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Surface Enhanced Raman Scattering ◽  
Silver Nanowire ◽  
Metal Nanostructures ◽  
Dna Molecules ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Raman scattering signals can be enhanced by several orders of magnitude on surface-enhanced Raman scattering (SERS) substrates made from noble metal nanostructures. Some SERS substrates are even able to detect single-molecule Raman signals. A novel silver nanobud (AgNB) substrate with superior SERS activity was fabricated with a solid-state ionics method. The AgNB substrate was formed by tightly collocated unidirectional 100 nm size silver buds, presenting a highly rough surface topography. Distinct SERS signals of singleλ-DNA molecules in water were detected on AgNB substrates. AgNB substrates were compared with disordered silver nanowire (AgNW) substrates manufactured by the same method through the SERS detection ofλ-DNA solutions. This original AgNB substrate provides a reliable approach towards trace analysis of biomacromolecules and promotes the utilization of the SERS technique in biomedical research.

scholarly journals Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 449
Author(s):  
Francesco Dell’Olio
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Liquid Biopsy ◽  
Tumor Imaging ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The recent improvements in diagnosis enabled by advances in liquid biopsy and oncological imaging significantly better cancer care. Both these complementary approaches, which are used for early tumor detection, characterization, and monitoring, can benefit from applying techniques based on surface-enhanced Raman scattering (SERS). With a detection sensitivity at the single-molecule level, SERS spectroscopy is widely used in cell and molecular biology, and its capability for the in vitro detection of several types of cancer biomarkers is well established. In the last few years, several intriguing SERS applications have emerged, including in vivo imaging for tumor targeting and the monitoring of drug release. In this paper, selected recent developments and trends in SERS applications in the field of liquid biopsy and tumor imaging are critically reviewed, with a special emphasis on results that demonstrate the clinical utility of SERS.

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