Influence of Potassium Ions on Act of Amphotericin B to the DPPC/Chol Mixed Monolayer at Different Surface Pressures

Amphotericin B (AmB) is an antifungal drug that rarely develops resistance. It has an affinity with the cholesterol on mammalian cell membranes, disrupting the structure and function of the membranes, which are also affected by potassium ions. However, the mechanism is unclear. In this paper, the Langmuir monolayer method was used to study the effects of potassium ions on the surface pressure–mean molecular area of isotherms, elastic modulus and the surface pressure–time curves of a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/cholesterol (DPPC/Chol) monolayer and a DPPC/Chol/AmB monolayer. The morphology and thickness of the Langmuir–Blodgett films were studied via atomic force microscopy. The results showed that AmB can increase the mean molecular area of the DPPC/Chol mixed monolayer at low pressures (15 mN/m) but reduces it at high pressures (30 mN/m). The potassium ions may interfere with the effect of AmB in different ways. The potassium ions can enhance the influence of AmB on the stability of monolayer at low surface pressures, but weaken it at high surface pressures. The potassium ions showed significant interference with the interaction between AmB and the cholesterol-enriched region. The results are helpful for us to understand how the effect of amphotericin B on the phospholipid membrane is interfered with by potassium ions when amphotericin B enters mammalian cell membrane.

Metallic Conduction and Carrier Localization in Two-Dimensional BEDO-TTF Charge-Transfer Solid Crystals

Charge-transfer salts based on bis(ethylenedioxy)tetrathiafulvalene (BEDO-TTF or BO for short) provide a stable two-dimensional (2D) metallic state, while the electrical resistance often shows an upturn at low temperatures below ~10 K. Such 2D weak carrier localization was first recognized for BO salts in the Langmuir–Blodgett films fabricated with fatty acids; however, it has not been characterized in charge-transfer solid crystals. In this paper, we discuss the carrier localization of two crystalline BO charge-transfer salts with or without magnetic ions at low temperatures through the analysis of the weak negative magnetoresistance. The phase coherence lengths deduced with temperature dependence are largely dominated by the electron–electron scattering mechanism. These results indicate that the resistivity upturn at low temperatures is caused by the 2D weak localization. Disorders causing elastic scattering within the metallic domains, such as those of terminal ethylene groups, should be suppressed to prevent the localization.

Nanoarchitectonics with porphyrins and related molecules

An emerging concept, nanoarchitectonics, is supposed to work on the preparation of functional materials systems from nanoscale components. Because porphyrin derivatives show their importance in many research targets, discussions on nanoarchitectonics with porphyrins and related molecules would provide meaningful opportunities to consider effective usages of the nanoarchitectonics. This review article explains various examples of nanoarchitectonics approaches with porphyrin derivatives. The examples are especially focused on two topics: (i) materials nanoarchitectonics for nanofibers, metal-organic frameworks, covalent organic frameworks, and hydrogen-bonded organic frameworks; (ii) interfacial nanoarchitectonics for surface monolayers (self-assembled monolayers), Langmuir-Blodgett films, and layer-by-layer assemblies. Functions and properties can be enhanced upon their organization in specific dimensions and arrangements in nanostructured frameworks. In many cases, interface-specific organization would lead to advanced performances with high efficiency and specificity. Even though only limited examples are described here, various possibilities are actually suggested. Not limited to porphyrin families, nanoarchitectonics for functional materials has to be considered with a wide range of materials.