Impact of Acid-Reducing Agents on Gastrointestinal Physiology and Design of Biorelevant Dissolution Tests to Reflect These Changes

2019 ◽  
Vol 108 (11) ◽  
pp. 3461-3477 ◽  
Author(s):  
Domagoj Segregur ◽  
Talia Flanagan ◽  
James Mann ◽  
Andrea Moir ◽  
Eva M. Karlsson ◽  
...  
Keyword(s):  
Reducing Agents ◽  
Gastrointestinal Physiology ◽  
Biorelevant Dissolution ◽  
Dissolution Tests

Can dosage form-dependent food effects be predicted using biorelevant dissolution tests? Case example extended release nifedipine

2016 ◽  
Vol 105 ◽  
pp. 193-202 ◽  
Author(s):  
Cord J. Andreas ◽  
Irena Tomaszewska ◽  
Uwe Muenster ◽  
Dorina van der Mey ◽  
Wolfgang Mueck ◽  
...  
Keyword(s):  
Dosage Form ◽  
Extended Release ◽  
Food Effects ◽  
Biorelevant Dissolution ◽  
Dissolution Tests

scholarly journals Biorelevant dissolution of candesartan cilexetil

ADMET & DMPK ◽  
2017 ◽  
Vol 5 (1) ◽  
pp. 39 ◽  
Author(s):  
Lucie Gruberová ◽  
Bohumil Kratochvil
Keyword(s):  
Dosage Form ◽  
Candesartan Cilexetil ◽  
Drug Formulation ◽  
Biorelevant Media ◽  
Solid Dosage ◽  
Biorelevant Dissolution ◽  
Dissolution Tests ◽  
Poorly Soluble ◽  
Form Development

<p class="ADMETabstracttext">The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation. Biorelevant media were developed for this purpose because dissolution media described in the International Pharmacopoeia are not thoroughly suitable. Therefore, we carried out solubility and dissolution tests in biorelevant media and we compared the results with data measured in compendial dissolution media. A shake-flask method and standard paddle apparatus were used. The concentration was measured by a UV-Vis spectrophotometer. An oral solid dosage form with poorly soluble drug candesartan cilexetil was tested. Significant differences in the solubility and dissolution profiles of candesartan cilexetil were observed. The study offers the overview of compendial and biorelevant media simulating fasted state that can be analyzed by a spectrophotometric technique.</p>

Development of Dissolution Tests on the Basis of Gastrointestinal Physiology

2005 ◽  
pp. 193-227 ◽  
Author(s):  
Sandra Klein ◽  
Martin Wunderlich ◽  
Erika Stippler ◽  
Jennifer Dressman
Keyword(s):  
Gastrointestinal Physiology ◽  
Dissolution Tests

Designing biorelevant dissolution tests for lipid formulations: Case example – Lipid suspension of RZ-50

2008 ◽  
Vol 69 (2) ◽  
pp. 776-785 ◽  
Author(s):  
Ekarat Jantratid ◽  
Niels Janssen ◽  
Hitesh Chokshi ◽  
Kin Tang ◽  
Jennifer B. Dressman
Keyword(s):  
Biorelevant Dissolution ◽  
Dissolution Tests ◽  
Lipid Formulations

Biorelevant Dissolution Tests with the Flow-Through Apparatus?

2000 ◽  
Vol 7 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Eleftheria Nicolaides ◽  
John M. Hempenstall ◽  
Christos Reppas
Keyword(s):  
Biorelevant Dissolution ◽  
Dissolution Tests ◽  
Flow Through

Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form

2009 ◽  
Vol 37 (3-4) ◽  
pp. 434-441 ◽  
Author(s):  
Ekarat Jantratid ◽  
Vincenzo De Maio ◽  
Emanuela Ronda ◽  
Valentina Mattavelli ◽  
Maria Vertzoni ◽  
...  
Keyword(s):  
Dosage Form ◽  
Diclofenac Sodium ◽  
Modified Release ◽  
Biorelevant Dissolution ◽  
Dissolution Tests

Methods for the Concentration of Bovine Ac-Globulin (Factor V)

1961 ◽  
Vol 06 (03) ◽  
pp. 435-444 ◽  
Author(s):  
Ricardo H. Landaburu ◽  
Walter H. Seegers
Keyword(s):  
Room Temperature ◽  
Barium Carbonate ◽  
Deae Cellulose ◽  
Reducing Agents ◽  
Factor V ◽  
Isoelectric Precipitation ◽  
Stabilizing Agent ◽  
Bovine Plasma ◽  
The Stability

SummaryAn attempt was made to obtain Ac-globulin from bovine plasma. The concentrates contain mostly protein, and phosphorus is also present. The stability characteristics vary from one preparation to another, but in general there was no loss before 1 month in a deep freeze or before 1 week in an icebox, or before 5 hours at room temperature. Reducing agents destroy the activity rapidly. S-acetylmercaptosuccinic anhydride is an effective stabilizing agent. Greatest stability was at pH 6.0.In the purification bovine plasma is adsorbed with barium carbonate and diluted 6-fold with water. Protein is removed at pH 6.0 and the Ac-globulin is precipitated at pH 5.0. Rivanol and alcohol fractionation is followed by chromatography on Amberlite IRC-50 or DEAE-cellulose. The final product is obtained by isoelectric precipitation.

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