In Vitro Human Skin Absorption of Solvent-Deposited Solids: Niacinamide and Methyl Nicotinate

2021 ◽  
Author(s):  
Gerald B. Kasting ◽  
Matthew A. Miller ◽  
Lijing Xu ◽  
Fang Yu ◽  
Joanna Jaworska
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Methyl Nicotinate

Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study

2019 ◽  
Vol 32 (3) ◽  
pp. 117-124 ◽  
Author(s):  
Sébastien Grégoire ◽  
Richard Cubberley ◽  
Hélène Duplan ◽  
Joan Eilstein ◽  
Nicola J. Hewitt ◽  
...  
Keyword(s):  
Human Skin ◽  
In Vitro Test ◽  
Skin Absorption ◽  
Absorption Study ◽  
Vitro Test

scholarly journals Anti-Aging Potential of Substance P-Based Hydrogel for Human Skin Longevity

2019 ◽  
Vol 20 (18) ◽  
pp. 4453 ◽  
Author(s):  
Da Jung Kim ◽  
Song Sun Chang ◽  
Jungsun Lee
Keyword(s):  
Substance P ◽  
Human Skin ◽  
Collagen Synthesis ◽  
Skin Penetration ◽  
Dermal Fibroblasts ◽  
Toxicity Tests ◽  
Skin Absorption ◽  
Collagen Production ◽  
Anti Inflammatory

Skin aging is generally caused by a decline in the components of the extracellular matrix (e.g., collagen and elastin) and due to inflammatory phenomena. Many growth factors and peptides with cell-growth and collagen-synthesis activities have shown promise in their application in anti-aging materials. However, the effect of collagen production, without anti-inflammatory effect, and skin penetration may not be enough for their use in anti-aging agents. Previously, we reported a substance P (SP)-based hydrogel (SP gel) that had potential wound-healing activities via induction of skin cell regeneration and collagen synthesis. Here, we analyzed the anti-aging activities and skin absorption effects of SP gel to extend its characterization. Toxicity tests, performed on human dermal fibroblasts (HDFs) and on a reconstructed 3D human skin model, indicated SP gel to be safe for long-term use, without causing irritation, even at high concentrations. In-vitro analysis revealed that SP gel elicited stronger collagen production activities than SP alone, and promoted anti-inflammatory effects with increased skin absorption properties. Moreover, SP gel did not induce melanin synthesis in a keratinocyte-melanocyte co-culture system. Together, the results suggest that SP gel has potential cosmetic effects and applicability as a novel ingredient in anti-aging products.

Human skin absorption of bis-2-(chloroethyl)sulphide (sulphur mustard)in vitro

2000 ◽  
Vol 20 (5) ◽  
pp. 349-355 ◽  
Author(s):  
R. P. Chilcott ◽  
J. Jenner ◽  
W. Carrick ◽  
S. A. M. Hotchkiss ◽  
P. Rice
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Sulphur Mustard

Desmosomal distribution in the epidermis of a non-contracting human skin equivalent

1992 ◽  
Vol 50 (1) ◽  
pp. 896-897
Author(s):  
L.X. Oakford ◽  
S.D. Dimitrijevich ◽  
R. Gracy
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Skin Equivalent ◽  
Tissue Component ◽  
Intact Skin ◽  
Similar Sequence ◽  
Sequence Of Events ◽  
Suprabasal Keratinocytes ◽  
Human Skin Equivalent

In intact skin the epidermal layer is a dynamic tissue component which is maintained by a basal layer of mitotically active cells. The protective upper epidermis, the stratum corneum, is generated by differentiation of the suprabasal keratinocytes which eventually desquamate as anuclear comeocytes. A similar sequence of events is observed in vitro in the non-contracting human skin equivalent (HSE) which was developed in this lab (1). As a part of the definition process for this model of living skin we are examining its ultrastructural features. Since desmosomes are important in maintaining cell-cell interactions in stratified epithelia their distribution in HSE was examined.

Human Skin-Derived Fibroblasts Acquire In Vitro Anti-Tumor Potential after Priming with Paclitaxel

2013 ◽  
Vol 13 (3) ◽  
pp. 523-530 ◽  
Author(s):  
Augusto Pessina ◽  
Valentina Cocce ◽  
Arianna Bonomi ◽  
Loredana Cavicchini ◽  
Francesca Sisto ◽  
...  
Keyword(s):  
Human Skin
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