scholarly journals An evolutionary conserved role of Wnt signaling in stem cell fate decision

2006 ◽  
Vol 289 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Regina Teo ◽  
Frank Möhrlen ◽  
Günter Plickert ◽  
Werner A. Müller ◽  
Uri Frank
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Decision ◽  
Stem Cell Fate ◽  
Fate Decision

scholarly journals Alternative splicing links histone modifications to stem cell fate decision

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Yungang Xu ◽  
Weiling Zhao ◽  
Scott D. Olson ◽  
Karthik S. Prabhakara ◽  
Xiaobo Zhou
Keyword(s):  
Stem Cell ◽  
Alternative Splicing ◽  
Cell Fate ◽  
Histone Modifications ◽  
Cell Fate Decision ◽  
Stem Cell Fate ◽  
Fate Decision

scholarly journals Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Nature ◽  
2012 ◽  
Vol 489 (7414) ◽  
pp. 150-154 ◽  
Author(s):  
Juan Song ◽  
Chun Zhong ◽  
Michael A. Bonaguidi ◽  
Gerald J. Sun ◽  
Derek Hsu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Cell Fate Decision ◽  
Neuronal Circuitry ◽  
Stem Cell Fate ◽  
Fate Decision

scholarly journals MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF-β Signaling

2016 ◽  
Vol 6 (3) ◽  
pp. 292-301 ◽  
Author(s):  
Christiana Hadjimichael ◽  
Christoforos Nikolaou ◽  
Joseph Papamatheakis ◽  
Androniki Kretsovali
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Fate ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Fine Tuning ◽  
Cell Fate Decision ◽  
Stem Cell Fate ◽  
Fate Decision

scholarly journals Alternative splicing links histone modifications to stem cell fate decision

2017 ◽  
Author(s):  
Yungang Xu ◽  
Weiling Zhao ◽  
Scott D. Olson ◽  
Karthik S. Prabhakara ◽  
Xiaobo Zhou
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Alternative Splicing ◽  
Cell Fate ◽  
Histone Modifications ◽  
Cell Fate Decision ◽  
Stem Cell Fate ◽  
Alternatively Spliced ◽  
Fate Decision ◽  
Alternatively Spliced Exons

AbstractBackgroundUnderstanding the embryonic stem cell (ESC) fate decision between self-renewal and proper differentiation is important for developmental biology and regenerative medicine. Attention has focused on mechanisms involving histone modifications, alternative pre-mRNA splicing, and cell-cycle progression. However, their intricate interrelations and joint contributions to ESC fate decision remain unclear.ResultsWe analyze the transcriptomes and epigenomes of human ESC and five types of differentiated cells. We identify thousands of alternatively spliced exons and reveal their development and lineage-dependent characterizations. Several histone modifications show dynamic changes in alternatively spliced exons and three are strongly associated with 52.8% of alternative splicing events upon hESC differentiation. The histone modification-associated alternatively spliced genes predominantly function in G2/M phases and ATM/ATR-mediated DNA damage response pathway for cell differentiation, whereas other alternatively spliced genes are enriched in the G1 phase and pathways for self-renewal. These results imply a potential epigenetic mechanism by which some histone modifications contribute to ESC fate decision through the regulation of alternative splicing in specific pathways and cell-cycle genes. Supported by experimental validations and extended dataset from Roadmap/ENCODE projects, we exemplify this mechanism by a cell cycle-related transcription factor, PBX1, which regulates the pluripotency regulatory network by binding to NANOG. We suggest that the isoform switch from PBX1a to PBX1b links H3K36me3 to hESC fate determination through the PSIP1/SRSF1 adaptor, which results in the exon skipping of PBX1.ConclusionWe reveal the mechanism by which alternative splicing links histone modifications to stem cell fate decision.

Sign in / Sign up

Export Citation Format

Share Document