075 — (SON0036) Activation and involvement of the lateral–posterior nucleus of the thalamus after a single generalized tonic–clonic seizure

Background Context. Cement leakage is not a rare complication of vertebroplasty, but ascending tonic clonic seizure syndrome is exceptionally rare. We herein report the first case to our knowledge of this complication related to vertebroplasty.Purpose. We herein report the first case of ascending tonic clonic seizure syndrome following epidural cement leakage after percutaneous vertebroplasty in a patient with multiple osteoporotic compression fractures.Study Design. Case report.Methods. A 64-year-old woman with T8, T10, L2, and L4 osteoporotic compression fractures underwent percutaneous vertebroplasty using polymethylmethacrylate. 40 minutes after the procedure the patient started suffering back and leg pain, having repetitive myoclonic jerks lasting 15 seconds of the lower extremities, spasm of the back, dyspnea, sinus tachycardia, hypoxemia, and metabolic acidosis.Results. The patient recovered completely due to a combination of early effective resuscitation and considered definitive management.Conclusions. Percutaneous vertebroplasty with polymethylmethacrylate is relatively safe but has few dangerous complications, which should be prevented by a meticulous technique and excellent image quality.

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Acute neurogenic pulmonary oedema following generalized tonic clonic seizure. A case report and a review of the literature

European Heart Journal ◽

10.1093/oxfordjournals.eurheartj.a062590 ◽

1988 ◽

Vol 9 (8) ◽

pp. 933-936 ◽

Cited By ~ 13

Author(s):

U. FREDBERG ◽

H. E. BøTKER ◽

F. K. RøMER

Keyword(s):

Case Report ◽

Pulmonary Oedema ◽

Clonic Seizure ◽

Tonic Clonic Seizure ◽

Review Of The Literature ◽

Neurogenic Pulmonary Oedema

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Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic–clonic seizure model in mice

Journal of Neural Transmission ◽

10.1007/s00702-018-1940-y ◽

2018 ◽

Vol 126 (2) ◽

pp. 115-122 ◽

Cited By ~ 1

Author(s):

Katarzyna M. Sawicka ◽

Agnieszka Wawryniuk ◽

Jadwiga Daniluk ◽

Sławomir Karwan ◽

Magdalena Florek-Łuszczki ◽

...

Keyword(s):

Antiepileptic Drugs ◽

Antiarrhythmic Drug ◽

Clonic Seizure ◽

Tonic Clonic Seizure ◽

Class Iii ◽

Class Iii Antiarrhythmic Drug ◽

Seizure Model

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Factors influencing the duration of generalized tonic–clonic seizure

Seizure ◽

10.1016/j.seizure.2015.11.008 ◽

2016 ◽

Vol 34 ◽

pp. 44-47 ◽

Cited By ~ 5

Author(s):

Sipei Pan ◽

Fang Wang ◽

Jing Wang ◽

Xiang Li ◽

Xingzhou Liu

Keyword(s):

Clonic Seizure ◽

Tonic Clonic Seizure ◽

Factors Influencing

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Pushing behavior and hemiparesis: which is critical for functional recovery in pusher patients ? Case report

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2007000300035 ◽

2007 ◽

Vol 65 (2b) ◽

pp. 536-539 ◽

Cited By ~ 9

Author(s):

Taiza E.G. Santos-Pontelli ◽

Octávio M. Pontes-Neto ◽

José Fernando Colafêmina ◽

Dráulio B. de Araújo ◽

Antônio Carlos Santos ◽

...

Keyword(s):

Case Report ◽

Barthel Index ◽

Functional Improvement ◽

Chronic Hypertension ◽

Acute Hemorrhage ◽

Lateral Posterior ◽

History Of ◽

Lateral Posterior Nucleus ◽

Neuroimaging Study ◽

The Right

We report a sequential neuroimaging study in a 48-years-old man with a history of chronic hypertension and lacunar strokes involving the ventral lateral posterior nucleus of the thalamus. The patient developed mild hemiparesis and severe contraversive pushing behavior after an acute hemorrhage affecting the right thalamus. Following standard motor physiotherapy, the pusher behavior completely resolved 3 months after the onset and, at that time, he had a Barthel Index of 85, although mild left hemiparesis was still present. This case report illustrates that pushing behavior itself may be severely incapacitating, may occur with only mild hemiparesis and affected patients may have dramatic functional improvement (Barthel Index 0 to 85) after resolution pushing behavior without recovery of hemiparesis.

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Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.65.9.1188 ◽

2019 ◽

Vol 65 (9) ◽

pp. 1188-1192

Author(s):

Erkan Kilinc ◽

Handan Gunes

Keyword(s):

Interleukin 1 ◽

Plasma Concentrations ◽

Onset Time ◽

Epileptic Seizures ◽

Clonic Seizure ◽

Tonic Clonic Seizure ◽

Interleukin 1 Beta ◽

Calcitonin Gene ◽

Epilepsy Treatment ◽

Dual Action

SUMMARY OBJECTIVE We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats. METHODS Ghrelin (80 µg/kg), obestatin (1 µg/kg), VIP (25 ng/kg) or saline were administered to rats intraperitoneally 30 min before pentylenetetrazole (PTZ, 50 mg/kg) injections. Stages of epileptic seizures were evaluated by Racine’s scale, and plasma CGRP, SP, and IL-1β concentrations were measured using ELISA. RESULTS Both obestatin and VIP shortened onset-time of generalized tonic-clonic seizure, respectively, moreover VIP also shortened the onset-time of first myoclonic-jerk induced by PTZ. While PTZ increased plasma CGRP, SP and IL-1β concentrations, ghrelin reduced the increases evoked by PTZ. While VIP further increased PTZ-evoked CGRP levels, it diminished IL-1β concentrations. However, obestatin did not change CGRP, SP, and IL-1β concentrations. CONCLUSION Our results suggest that ghrelin acts as an anticonvulsant, obestatin acts as a proconvulsant, and VIP has dual action on epilepsy. Receptors of those neuropeptides may be promising targets for epilepsy treatment.

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Simultaneous Bilateral Femoral Neck Fracture Due to a Tonic-Clonic Seizure and High-Dose Steroid Therapy

Arthroplasty Today ◽

10.1016/j.artd.2020.05.013 ◽

2020 ◽

Vol 6 (3) ◽

pp. 513-516

Author(s):

Fernando Diaz Dilernia ◽

Martin M. Estefan ◽

Gerardo Zanotti ◽

Fernando Comba ◽

Francisco Piccaluga ◽

...

Keyword(s):

Femoral Neck ◽

Femoral Neck Fracture ◽

Steroid Therapy ◽

Clonic Seizure ◽

Tonic Clonic Seizure ◽

High Dose ◽

High Dose Steroid ◽

Neck Fracture

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Obsessive compulsive symptoms in patients with primary generalized and partial onset epilepsy

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20181019 ◽

2018 ◽

Vol 6 (4) ◽

pp. 1183

Author(s):

Sagar Lavania ◽

Mohd. Aleem Siddiqui ◽

Shantanu Bharti ◽

Abhishek Kumar

Keyword(s):

Clonic Seizure ◽

Tonic Clonic Seizure ◽

Seizure Type ◽

Check List ◽

Onset Seizure ◽

Obsessive Compulsive ◽

Obsessive Compulsive Symptoms ◽

Partial Onset Seizure ◽

The Mean ◽

Patients With Epilepsy

Background: To find out and compare the obsessive-compulsive symptoms / disorder among patients of primary generalized and partial onset epilepsy.Methods: Patients with epilepsy diagnosed clinically at psychiatric out patient’s department were selected for the study and categorized as primary generalized onset tonic clonic seizure type and partial onset seizure. Yale-Brown obsessive-compulsive symptoms check list and scale was applied to find out the obsessive-compulsive symptoms.Results: A total of 110 patients were categorized as primary generalized (GE) 49 and partial onset epilepsy (PE) 61 patients. Obsessive-Compulsive Symptoms (OCS) were found to be 19.9%, and OCD among 3.63%. Mean Y-BOCS scores for obsession were found to be 3.77±1.93 and 4.93±2.03, (t = -3.034, df= 108, p= .003). Whereas the mean Y-BOCS compulsions score was 2.93±1.96 and 4.62±1.87 was (t = -4.590, df= 108, p= .000) for GE and PE group respectively.Conclusions: OCD and OCS among the epilepsy patients were found to be 3.63%, and 19.9% respectively, and significantly higher mean obsessive and compulsive score were found for the group of partial onset epilepsy.

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