scholarly journals Obsessive compulsive symptoms in patients with primary generalized and partial onset epilepsy

Author(s):  
Sagar Lavania ◽  
Mohd. Aleem Siddiqui ◽  
Shantanu Bharti ◽  
Abhishek Kumar

Background: To find out and compare the obsessive-compulsive symptoms / disorder among patients of primary generalized and partial onset epilepsy.Methods: Patients with epilepsy diagnosed clinically at psychiatric out patient’s department were selected for the study and categorized as primary generalized onset tonic clonic seizure type and partial onset seizure. Yale-Brown obsessive-compulsive symptoms check list and scale was applied to find out the obsessive-compulsive symptoms.Results: A total of 110 patients were categorized as primary generalized (GE) 49 and partial onset epilepsy (PE) 61 patients. Obsessive-Compulsive Symptoms (OCS) were found to be 19.9%, and OCD among 3.63%. Mean Y-BOCS scores for obsession were found to be 3.77±1.93 and 4.93±2.03, (t = -3.034, df= 108, p= .003). Whereas the mean Y-BOCS compulsions score was 2.93±1.96 and 4.62±1.87 was (t = -4.590, df= 108, p= .000) for GE and PE group respectively.Conclusions: OCD and OCS among the epilepsy patients were found to be 3.63%, and 19.9% respectively, and significantly higher mean obsessive and compulsive score were found for the group of partial onset epilepsy.

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Jason A. Chen ◽  
Katherine M. Unverferth ◽  
Erick H. Cheung

Among atypical antipsychotics, quetiapine is commonly prescribed and considered to have a favorable side effect and safety profile. Here, we report the case of a patient who developed a generalized tonic-clonic seizure 28 hours following ingestion of 1,400 mg of quetiapine. Review of the literature identifies delayed-onset seizure as a potential complication of quetiapine overdose. Unique to this case, delayed-onset seizures occurred in a patient with a relatively low dose of quetiapine and no obvious toxidrome, suggesting that this reaction may be an important consideration in the management of quetiapine overdose. The pharmacokinetics and pharmacodynamics of quetiapine may explain this unusual phenomenon.


2021 ◽  
Vol 2 (2) ◽  
pp. 77-85
Author(s):  
Taalia Khan ◽  
Karin Österman ◽  
Kaj Björkqvist

The aim of the study was to investigate victimisation of married women from aggression perpetrated by the mothers-in-law, and its psychological concomitants. A questionnaire was completed by 569 married women in Pakistan. The mean age was 31.4 years (SD 9.1). Mothers-in-law perpetrated more verbal and indirect aggression than physical aggression against their daughters-in-law. Anxiety, depression, obsessive compulsive symptoms, and somatisation were all associated with aggression perpetrated by the mothers-in-law. The mothers-in-law had significantly more often than the husbands perpetrated indirect aggression against the daughters-in-law, while the husbands had perpetrated both physical and verbal aggression against their wife significantly more often than the mothers-in-laws. It was concluded that aggression perpetrated by mothers-in-law is a significant problem and associated with mental health problems in married Pakistani women.


Neurology ◽  
2020 ◽  
Vol 95 (14) ◽  
pp. e2009-e2015
Author(s):  
Sándor Beniczky ◽  
Guido Rubboli ◽  
Athanasios Covanis ◽  
Michael R. Sperling

ObjectiveTo test the hypothesis that absence seizures can evolve to generalized tonic-clonic seizures, we documented electroclinical features of this novel seizure type.MethodsIn 4 large video-EEG databases, we identified recordings of seizures starting with impaired awareness that, without returning to baseline interictal state, evolved to generalized tonic-clonic seizures. We extracted the detailed semiologic and electrographic characteristics of these seizures, and we documented the clinical background, diagnoses, and therapeutic responses in these patients.ResultsWe identified 12 seizures from 12 patients. All seizures started with a period of impaired awareness and bursts of generalized spike or polyspike and slow-wave discharges, the hallmark of absence seizures. Without returning to baseline, the nonmotor (absence) phase was followed by tonic-clonic convulsions. We called this novel generalized seizure type absence-to-bilateral-tonic-clonic seizure. Most patients had idiopathic generalized epilepsies, although with a high incidence of unusual features and poor therapeutic response.ConclusionsAbsence-to-bilateral-tonic-clonic seizures are a novel generalized seizure type. Clinicians should be aware of this seizure for correctly diagnosing patients. This novel seizure type may further elucidate generalized ictogenesis.


2011 ◽  
Vol 26 (S2) ◽  
pp. 1220-1220
Author(s):  
A. Afkhamebrahimi

ObjectiveThe impact of typical and atypical anti-psychotics on developing obsessive-compulsive symptoms in schizophrenic patients were investigated in this study.Materials and methods64 schizophrenic patients (32 cases in typical anti-psychotics group and 32 in atypical anti-psychotics group) participated in the study. All the patients first interviewed by SCID and then Yale Brown Obsessive-Compulsive Scale (Y-BOCS) and Brief psychiatric Rating Scale were administered in the beginning, 3 weeks and 6 weeks after treatment. The Data then transferred to SPSS program. for analysis.ResultsIn typical group the mean scores of Y-BOCS were 2.40, 2.30 and 2.18 in the beginning, 3 weeks and 6 weeks after treatment. In atypical group the mean scores of Y-BOCS were 4.12, 4.46 and 4.53 in three trials. There were no significant differences in the mean scores of Y-BOCS of two group in the beginning of the trial although a trend toward significance was observed but the differences between scores were significant in trial 2 (3 weeks) and trial 3 (6 weeks).DiscussionBased on this study and in line with previous studies, atypical anti-psychotics may induce obsessive compulsive symptoms (although mild) in patients with schizophrenia.


1999 ◽  
Vol 16 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Shoumitro Deb ◽  
Joseph Joyce

AbstractObjectives: The purpose of the study was to define various aspects of epilepsy in a population based sample of adults with a learning disability.Method: A purpose-designed questionnaire was used to collect information on various aspects of epilepsy on 143 adults with a learning disability and epilepsy. Names of these subjects were collected from a hospital for learning disabled adults, specialist epilepsy clinics and social services department. Data was gathered from case notes and direct patient examination.Results: Generalised tonic clonic seizure was the most common seizure type. Seventy-three per cent sustained a seizure within the previous 12 months of the study. Abnormal EEG findings including excessive slow background activities and epileptiform waves were documented in a high proportion of subjects with a learning disability and epilepsy.Conclusions: Both resistant epilepsy and generalised tonic clonic seizures seem to be more frequent among the learning disabled population compared with the general population.


1977 ◽  
Vol 131 (1) ◽  
pp. 75-78 ◽  
Author(s):  
J. H. Dowson

SummaryThe case histories are examined of 41 patients who were admitted to hospital for the first time with a diagnosis of obsessive-compulsive neurosis. Aspects of the phenomenology are reported which presented between the first appearance of obsessive-compulsive symptoms and discharge from the first admission.The mean age for admission was 31·6 years (SD 14·3) and 68 per cent of the sample were women. The women showed significantly higher incidences of contamination phobia and of compulsive cleaning behaviour than did the men. Cleaning behaviour and avoidance of feared stimuli were the most frequently encountered manifestations of compulsive behaviour.


2020 ◽  
Vol 102 ◽  
pp. 106640
Author(s):  
Esin Evren Kilicaslan ◽  
H.Sabiha Türe ◽  
Meltem İzci Kasal ◽  
Nebile Nur Çavuş ◽  
Dilek Altın Akyüz ◽  
...  

2007 ◽  
Vol 31 (2) ◽  
pp. 49-52 ◽  
Author(s):  
Lynne M. Drummond ◽  
Anusha Pillay ◽  
Peter Kolb ◽  
Shashi Rani

Aims and MethodA naturalistic study was conducted to examine the outcome on self-report and observer-rated measures in patients with severe, chronic, resistant obsessive–compulsive disorder (OCD) admitted to a specialised in-patient unit.ResultsTwenty-six patients were admitted over the study period. The mean age of all patients was 37 years (s.d.=13.8, range 18–61 years) and they had a mean duration of OCD of 18.4 years (s.d.=10.9, range 4–40 years). Instruments measuring severity demonstrated a 37–67% reduction in obsessive–compulsive symptoms and a 64% reduction in depressive symptoms after an average of almost 15 weeks in hospital.Clinical ImplicationsThis study demonstrates that specialised in-patient care can benefit a small group of severely ill patients with OCD who fail to respond to treatment in primary and secondary care.


2019 ◽  
Vol 27 (2 (99)) ◽  
pp. 59-62
Author(s):  
Volodymyr Kharytonov

The paper presents the results of a comprehensive study of the characteristics of the psychopathological state of patients with epilepsy and depressions of various genesis (organic, psychogenic and endogenous) in the interi ctal period. Were investigated the severity and structure of psychopathological manifestations, as well as separately the level and structure of anxiety in patients with epilepsy depending on the form of depression in a comparative aspect with patients with epilepsy without signs of depression. According to the selected forms of depression, are analyzed the severity and structural features of depressive symptoms. Was established that patients with depressions are characterized by more pronounced and diverse psychopathological manifestations, in the structure of which, apart from depressive manifestations, anxious and psychosomatic symptoms are formed (with organic and psychogenic depressions); as well as asthenic manifestations, a decrease in the level of interpersonal interaction and obsessive-compulsive symptoms (with endogenous depressions). Is determined the highest level of psychopathological distress in patients with epilepsy with endogenous depressions. Key words: epilepsy, organic depression, psychogenic depression, endogenous depression, interictal period, psychopathological condition, anxiety, depressive manifestations.


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