Autism spectrum disorder, social communication difficulties, and developmental comorbidities in Sturge–Weber syndrome

An increasing number of school children are diagnosed with Autism Spectrum Disorder (ASD). These children may be referred for assessments for a variety of reasons, including to assess for intellectual impairments, eligibility for support, or to monitor progress. Characteristics of ASD, such as social communication difficulties, as well as common comorbid conditions and behaviours, may make such assessments more challenging than for assessments with children without ASD. The present article overviews characteristics of ASD, challenges with assessment, and strategies to choose, prepare for, and complete a standardised assessment to provide information to assist psychologists and other professionals to complete a valid assessment of a child with ASD. Resources and recommendations for further reading are provided.

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Short report: Social communication difficulties and restricted repetitive behaviors as predictors of anxiety in adults with autism spectrum disorder

Autism ◽

10.1177/1362361320934218 ◽

2020 ◽

Vol 24 (7) ◽

pp. 1917-1923

Author(s):

Erika Kuzminskaite ◽

Sander Begeer ◽

Rosa A Hoekstra ◽

Rachel Grove

Keyword(s):

Autism Spectrum Disorder ◽

Social Communication ◽

Autism Spectrum ◽

Anxiety Symptoms ◽

Repetitive Behaviors ◽

Spectrum Disorder ◽

Autism Spectrum Quotient ◽

Communication Difficulties ◽

Autistic Adults ◽

Order Restricted

Autism spectrum disorder and anxiety are highly comorbid conditions. Understanding the underlying traits of anxiety in autism spectrum disorder is crucial to prevent and treat it efficiently. Hence, this study determined whether social communication difficulties or restricted repetitive behaviors are stronger risk factors for anxiety symptoms in autistic adults in a large cohort. Data on 742 autistic adults from the Netherlands Autism Register were included in the study. Hierarchical regression was implemented to evaluate whether social communication difficulties (Autism-Spectrum Quotient social behavior factor) and restricted repetitive behaviors (Adult Routines Inventory) were predictive of anxiety (Hospital Anxiety and Depression Scale) controlling for age and sex. When considered together, restricted repetitive behaviors stood out as significant positive predictors of anxiety symptoms (lower-order restricted repetitive behaviors, β = 0.32, p < 0.001; higher-order restricted repetitive behaviors, β = 0.15, p = 0.001), whereas social communication difficulties did not ( β = 0.06, p = 0.11). Sex did not moderate these associations ( p > 0.05). Non-social autistic traits are stronger predictors of anxiety symptoms than social traits in autistic adults. Increased attention to restricted repetitive behaviors should be given to improve current support programs for autistic adults with anxiety and to identify autistic individuals at risk.

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Emotion Dysregulation in Autism Spectrum Disorder

The Oxford Handbook of Emotion Dysregulation ◽

10.1093/oxfordhb/9780190689285.013.20 ◽

2018 ◽

pp. 282-298

Author(s):

Emily Neuhaus

Keyword(s):

Autism Spectrum Disorder ◽

Social Communication ◽

Educational Outcomes ◽

Emotion Dysregulation ◽

Research Priorities ◽

Theoretical Models ◽

Autism Spectrum ◽

Repetitive Behaviors ◽

Spectrum Disorder

Autism spectrum disorder (ASD) is defined by deficits in social communication and interaction, and restricted and repetitive behaviors and interests. Although current diagnostic conceptualizations of ASD do not include emotional difficulties as core deficits, the disorder is associated with emotion dysregulation across the lifespan, with considerable implications for long-term psychological, social, and educational outcomes. The overarching goal of this chapter is to integrate existing knowledge of emotion dysregulation in ASD and identify areas for further investigation. The chapter reviews the prevalence and expressions of emotion dysregulation in ASD, discusses emerging theoretical models that frame emotion dysregulation as an inherent (rather than associated) feature of ASD, presents neurobiological findings and mechanisms related to emotion dysregulation in ASD, and identifies continuing controversies and resulting research priorities.

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Teaching Social Scripts to Improve Social Communication for Students With Autism Spectrum Disorder

Teaching Exceptional Children ◽

10.1177/00400599211022023 ◽

2021 ◽

pp. 004005992110220

Author(s):

Gretchen Scheibel ◽

Zijie Ma ◽

Jason C. Travers

Keyword(s):

Autism Spectrum Disorder ◽

Social Communication ◽

Challenging Behaviors ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Evidence Based ◽

Academic Difficulties ◽

Evidence Based Practices ◽

Social Scripts ◽

Students With Autism

Students with Autism Spectrum Disorder are likely to demonstrate social impairments that contribute to challenging behaviors and academic difficulties. As a result, the task of improving social communication skills is a critical component to any educational program for this population. Scripting provides an evidence-based and versatile option for improving social communication, yielding valuable results while requiring limited time and resource preparation from educators. In this article, we present step by step guidance to support practitioners in using scripting interventions. Considerations are discussed for adapting this intervention to meet the needs of students across the autism spectrum and links to resources for strengthening implementation and including other evidence-based practices.

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Cariprazine alleviates core behavioral deficits in the prenatal valproic acid exposure model of autism spectrum disorder

Psychopharmacology ◽

10.1007/s00213-021-05851-6 ◽

2021 ◽

Author(s):

Viktor Román ◽

Nika Adham ◽

Andrew G. Foley ◽

Lynsey Hanratty ◽

Bence Farkas ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Social Communication ◽

Partial Agonist ◽

Social Play ◽

Autism Spectrum ◽

Social Recognition ◽

Repetitive Behaviors ◽

Spectrum Disorder ◽

Exposure Model ◽

Behavioral Deficits

Abstract Rationale Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction and restricted, repetitive behaviors. The unmet medical need in ASD is considerable since there is no approved pharmacotherapy for the treatment of these deficits in social communication, interaction, and behavior. Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist, is already approved for the treatment of schizophrenia and bipolar I disorder in adults; investigation in patients with ASD is warranted. Objectives The aim of this study was to investigate the effects of cariprazine, compared with risperidone and aripiprazole, in the rat prenatal valporic acid (VPA) exposure model on behavioral endpoints representing the core and associated symptoms of ASD. Methods To induce the ASD model, time-mated Wistar rat dams were treated with VPA during pregnancy. Male offspring were assigned to groups and studied in a behavioral test battery at different ages, employing social play, open field, social approach-avoidance, and social recognition memory tests. Animals were dosed orally, once a day for 8 days, with test compounds (cariprazine, risperidone, aripiprazole) or vehicle before behavioral assessment. Results Cariprazine showed dose-dependent efficacy on all behavioral endpoints. In the social play paradigm, only cariprazine was effective. On the remaining behavioral endpoints, including the reversal of hyperactivity, risperidone and aripiprazole displayed similar efficacy to cariprazine. Conclusions In the present study, cariprazine effectively reversed core behavioral deficits and hyperactivity present in juvenile and young adult autistic-like rats. These findings indicate that cariprazine may be useful in the treatment of ASD symptoms.

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FASTER and SCOTT&EVA trainings for adults with high-functioning autism spectrum disorder (ASD): study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-021-05205-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Ludger Tebartz van Elst ◽

Thomas Fangmeier ◽

Ulrich Max Schaller ◽

Oliver Hennig ◽

Meinhard Kieser ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Social Communication ◽

Primary Outcome ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Social Responsiveness ◽

Evidence Based ◽

Computer Based Training ◽

Randomized Controlled ◽

Computer Based

Abstract Background Autism spectrum disorder (ASD) is a chronic neurodevelopmental condition with a prevalence rate above 1%, characterized by deficits in social communication and interaction; restrictive, repetitive patterns of behavior, interests, or activities; and a preference for sameness and routines. The majority of adult ASD patients suffer from comorbid conditions such as depression and anxiety. Therapy options for adult ASD patients are lacking, with presently no available evidence-based interventions in Germany. Recently, two interventions to improve social responsiveness have been published. FASTER (“Freiburger Asperger-Spezifische Therapie für ERwachsene” = Freiburg Asperger-specific therapy for adults) is a manualized group psychotherapy program including three modules on psychoeducation, stress regulation management, and non-verbal and verbal social communication training with videotaped tasks. SCOTT&EVA (“Social Cognition Training Tool”, and its enhancement “Emotionen Verstehen und Ausdruecken” = understanding and expressing emotions) is a computer-based training program to enhance social cognition including video and audio material of emotional expressions and complex real-life social situations. Initial studies for both programs have shown good feasibility and efficacy. Methods Three hundred sixty adult participants with an autism spectrum disorder (ASD) will take part in a randomized controlled three-armed multi-center trial to prove the efficacy of manualized group psychotherapy and a manualized computer-based training program. Both interventions will be compared with a treatment as usual (TAU) group, aiming to establish evidence-based psychotherapy approaches for adult individuals with ASD. The primary outcome is evaluated by parents, spouses, or others who have sufficient insight into the respective participant’s social communication and interaction, and will be measured with the Social Responsiveness Scale. First, each of both interventions will be compared to TAU. If at least one of the differences is significant, both interventions will be compared against each other. The primary outcome will be measured at baseline (T0) and 4 months after baseline (T1). Discussion The trial is the first to validate psychiatric therapeutic and training interventions for adult ASD patients in Germany. A trial is needed because the prevalence of ASD in adulthood without intellectual disability is high, and no evidence-based intervention can be offered in Germany. Trial registration German Clinical Trial Register DRKS00017817. Registered on 20 April 2020.

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