Valproate and folate: Congenital and developmental risks

2020 ◽  
Vol 108 ◽  
pp. 107068 ◽  
Author(s):  
Edward H. Reynolds ◽  
Ralph Green
Keyword(s):  
2009 ◽  
Vol 11 (1) ◽  
pp. 41-67 ◽  
Author(s):  
M.E. Kalverboer ◽  
A.E. Zijlstra ◽  
E.J. Knorth

This study examines the European legal framework and policy on children’s rights and on the development and developmental risks of children from asylum-seeking families who have lived in asylum centres for over five years with the prospect of being forced to return to their home country. The legal procedures and practices of Member States in the Western European countries seem to be far too lengthy, and the standards for reception far too low to protect the children’s positive development.


2014 ◽  
Vol 36 (4) ◽  
pp. 361-362
Author(s):  
Amaury Cantilino ◽  
Laura Lorenzo ◽  
Juliane dos A. de Paula ◽  
Adrienne Einarson

Author(s):  
Christof Schaefer

Pregnancy-related information provided by leaflets usually contains inadequate data to interpret risks of teratogenicity; and in the absence of data, prescribing information often recommends discontinuing use in anticipation of and during pregnancy. In contrast, individual information on drug risk assessment addresses three different clinical perspectives: 1) looking for drugs of choice or planning pregnancy under medication; 2) assessment of drugs’ risk after exposure during an unplanned pregnancy; 3) assessment of causality in cases of adverse pregnancy outcomes in association with drug exposure. Unfortunately, for many women with chronic rheumatic diseases, discontinuation of all medication leaves an unacceptable risk of disease reactivation. Although, for the majority of drugs, human data are still insufficient to rule out developmental risks it is possible to distinguish antirheumatic drugs of choice with apparently low or negligible risks from those with scarce data or controversies on their safety and those with evidenced risk for the unborn.


1932 ◽  
Vol 7 (1) ◽  
pp. 47-58 ◽  
Author(s):  
N. William Ingalls
Keyword(s):  

2001 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
J Gordon Millichap
Keyword(s):  

2008 ◽  
Vol 13 (4) ◽  
pp. 255-266 ◽  
Author(s):  
Claudia M. Haase ◽  
Martin J. Tomasik ◽  
Rainer K. Silbereisen

Timing matters in the development of adolescents’ behavioral autonomy. Drawing from two German national surveys, the present studies showed that premature curfew autonomy (measured retrospectively) was associated with developmental risks in late adolescence (16–21 years, assessed in 1996) and young adulthood (25–30 years, assessed in 2005). Premature individuals neither experienced socioeconomic disadvantages nor had lower educational aspirations in late adolescence, but they attained lower levels of education in young adulthood. Premature curfew autonomy was further associated with maladjustment regarding certain developmental challenges of late adolescence (higher deviant behavior, lower disclosure, higher identity diffusion, and lower planfulness) and young adulthood (no differences in employment and partnership status, but higher demands of social change in work, family, and public life). Finally, premature curfew autonomy was related to lower subjective well-being in late adolescence and young adulthood.


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