Abstract
A recent study published in The Lancet predicts a remarkable drop in population numbers following a peak that will be reached by 2064. A unique feature of the upcoming population drop is that it will be almost exclusively caused by decreased reproduction, rather than factors that increase rates of mortality. The reasons for decreased reproduction are also unique, as, unlike previous centuries, limited reproduction today is hardly due to a shortage in resources. In other words, the predicted population drop is almost exclusively due to changes in reproductive behavior and reproductive physiology. Today, global changes in reproductive behavior are mostly explained by social sciences in a framework of demographic transition hypotheses, while changes in reproductive physiology are usually attributed to effects of endocrine-disrupting pollutants. This review outlines a complementary/alternative hypothesis, which connects reproductive trends with population densities. Numerous wildlife and experimental studies of a broad range of animal species have demonstrated that reproductive behavior and reproductive physiology are negatively controlled via endocrine and neural signaling in response to increasing population densities. The causal chain of this control system, although not fully understood, includes suppression of every level of hypothalamic-pituitary-gonadal cascade by hypothalamic-pituitary-adrenal axis, activated in response to increasing stress of social interactions. This paper discusses evidence in support of a hypothesis that current trends in reproductive physiology and behavior may be partly explained by increasing population densities. Better understanding of the causal chain involved in reproduction suppression by population density–related factors may help in developing interventions to treat infertility and other reproductive conditions.
Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior