Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial

2011 ◽  
Vol 2011 ◽  
pp. 147-148
Author(s):  
M.F. Picco
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multicentre Trial ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Clinical Recurrence ◽  
Endoscopic Recurrence

scholarly journals P229 The modified postoperative endoscopic recurrence score for Crohn's disease: Does it really make a difference in predicting clinical recurrence?

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S194-S194
Author(s):  
P. Rivière ◽  
S. Vermeire ◽  
G. Van Assche ◽  
P. Rutgeerts ◽  
A. De Buck van Overstraeten ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Recurrence Score ◽  
Clinical Recurrence ◽  
Endoscopic Recurrence

Final Report on a Placebo-Controlled, Double-Blind, Randomized, Multicentre Trial of Cyclosporin Treatment in Active Chronic Crohn's Disease

1991 ◽  
Vol 26 (7) ◽  
pp. 689-695 ◽  
Author(s):  
J. Brynskov ◽  
L. Freund ◽  
S. Nørby Rasmussen ◽  
K. Lauritsen ◽  
O. Schaffalitzky De Muckadell ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multicentre Trial ◽  
Final Report ◽  
Double Blind ◽  
Cyclosporin Treatment

The relationship between endoscopic and clinical recurrence in postoperative Crohn’s disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Alessandro Ble ◽  
Cecilia Renzulli ◽  
Fabio Cenci ◽  
Maria Grimaldi ◽  
Michelangelo Barone ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Mixed Effects ◽  
Spearman Correlation ◽  
Clinical Recurrence ◽  
Endoscopic Recurrence ◽  
Meta Regression ◽  
The Relationship

Abstract Background and Aims We aimed to quantify the magnitude of the association between endoscopic recurrence and clinical recurrence [symptom relapse] in patients with postoperative Crohn’s disease. Methods Databases were searched to October 2, 2020 for randomised controlled trials [RCTs] and cohort studies of adult patients with Crohn’s disease with ileocolonic resection and anastomosis. Summary effect estimates for the association between clinical recurrence and endoscopic recurrence were quantified by risk ratios [RR] and 95% confidence intervals [95% CI]. Mixed-effects meta-regression evaluated the role of confounders. Spearman correlation coefficients were calculated to assess the relationship between these outcomes as endpoints in RCTs. An exploratory mixed-effects meta-regression model with the logit of the rate of clinical recurrence as the outcome and the rate of endoscopic recurrence as a predictor was also evaluated. Results Thirty-seven studies [N=4053] were included. For 8 RCTs with available data, the RR for clinical recurrence for patients who experienced endoscopic recurrence was 10.77 [95% CI 4.08-28.40; GRADE moderate certainty evidence]; the corresponding estimate from 11 cohort studies was 21.33 [95% CI 9.55-47.66; GRADE low certainty evidence]. A single cohort study showed a linear relationship between Rutgeerts score and clinical recurrence risk. There was a strong correlation between endoscopic recurrence and clinical recurrence treatment effect estimates as trial outcomes [weighted Spearman correlation coefficient 0.51]. Conclusions The associations between endoscopic recurrence and subsequent clinical recurrence lend support to the choice of endoscopic recurrence to monitor postoperative disease activity and as a primary endpoint in clinical trials of postoperative Crohn’s disease.

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