A serotonin receptor antagonist, but not melatonin, modulates hormonal responses to capture stress in two populations of garter snakes (Thamnophis sirtalis parietalis and Thamnophis sirtalis concinnus)

2005 ◽  
Vol 141 (3) ◽  
pp. 259-270 ◽  
Author(s):  
Deborah I. Lutterschmidt ◽  
Robert T. Mason
Keyword(s):  
Receptor Antagonist ◽  
Serotonin Receptor ◽  
Thamnophis Sirtalis ◽  
Garter Snakes ◽  
Hormonal Responses ◽  
Thamnophis Sirtalis Parietalis ◽  
Capture Stress ◽  
Serotonin Receptor Antagonist ◽  
Two Populations

scholarly journals Multi-Tissue Transcriptomic-Informed In Silico Investigation of Drugs for the Treatment of Dengue Fever Disease

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1540
Author(s):  
Beatriz Sierra ◽  
Ana Cristina Magalhães ◽  
Daniel Soares ◽  
Bruno Cavadas ◽  
Ana B. Perez ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Dengue Fever ◽  
In Silico ◽  
Serotonin Receptor ◽  
Neglected Tropical Diseases ◽  
Dengue Infection ◽  
Severe Dengue ◽  
Functional Evaluation ◽  
Atpase Inhibitor ◽  
Serotonin Receptor Antagonist

Transcriptomics, proteomics and pathogen-host interactomics data are being explored for the in silico–informed selection of drugs, prior to their functional evaluation. The effectiveness of this kind of strategy has been put to the test in the current COVID-19 pandemic, and it has been paying off, leading to a few drugs being rapidly repurposed as treatment against SARS-CoV-2 infection. Several neglected tropical diseases, for which treatment remains unavailable, would benefit from informed in silico investigations of drugs, as performed in this work for Dengue fever disease. We analyzed transcriptomic data in the key tissues of liver, spleen and blood profiles and verified that despite transcriptomic differences due to tissue specialization, the common mechanisms of action, “Adrenergic receptor antagonist”, “ATPase inhibitor”, “NF-kB pathway inhibitor” and “Serotonin receptor antagonist”, were identified as druggable (e.g., oxprenolol, digoxin, auranofin and palonosetron, respectively) to oppose the effects of severe Dengue infection in these tissues. These are good candidates for future functional evaluation and clinical trials.

SEROTONIN RECEPTOR ANTAGONIST INDUCES INDEFINITE SURVIVAL OF FULLY-ALLOGENEIC CARDIAC GRAFTS.

2004 ◽  
Vol 78 ◽  
pp. 599-600
Author(s):  
T Akiyoshi ◽  
Q Zhang ◽  
F Inoue ◽  
K Tanaka ◽  
O Aramaki ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Serotonin Receptor ◽  
Serotonin Receptor Antagonist

Effectiveness of Serotonin-Receptor Antagonist Antiemetic Therapy over Successive Courses of Carboplatin-Based Chemotherapy

2002 ◽  
Vol 85 (3) ◽  
pp. 435-437 ◽  
Author(s):  
Margaret R. Markman ◽  
Gertrude Peterson ◽  
Barbara Kulp ◽  
Maurie Markman
Keyword(s):  
Receptor Antagonist ◽  
Serotonin Receptor ◽  
Antiemetic Therapy ◽  
Serotonin Receptor Antagonist
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