The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms

2017 ◽  
Vol 111 ◽  
pp. 51-60 ◽  
Author(s):  
Randi J. Parks ◽  
Oleg Bogachev ◽  
Martin Mackasey ◽  
Gibanananda Ray ◽  
Robert A. Rose ◽  
...  
Keyword(s):  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Cardiac Excitation ◽  
The Impact

Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction

2001 ◽  
Vol 280 (5) ◽  
pp. H1928-H1944 ◽  
Author(s):  
Gregory R. Ferrier ◽  
Susan E. Howlett
Keyword(s):  
Membrane Potential ◽  
Regulatory Mechanism ◽  
Cardiac Contraction ◽  
Release Mechanism ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Regulation Of Contraction ◽  
Cardiac Excitation ◽  
The Impact

The steps that couple depolarization of the cardiac cell membrane to initiation of contraction remain controversial. Depolarization triggers a rise in intracellular free Ca2+ which activates contractile myofilaments. Most of this Ca2+ is released from the sarcoplasmic reticulum (SR). Two fundamentally different mechanisms have been proposed for SR Ca2+ release: Ca2+-induced Ca2+ release (CICR) and a voltage-sensitive release mechanism (VSRM). Both mechanisms operate in the same cell and may contribute to contraction. CICR couples the release of SR Ca2+ closely to the magnitude of the L-type Ca2+ current. In contrast, the VSRM is graded by membrane potential rather than Ca2+ current. The electrophysiological and pharmacological characteristics of the VSRM are strikingly different from CICR. Furthermore, the VSRM is strongly modulated by phosphorylation and provides a new regulatory mechanism for cardiac contraction. The VSRM is depressed in heart failure and may play an important role in contractile dysfunction. This review explores the operation and characteristics of the VSRM and CICR and discusses the impact of the VSRM on our understanding of cardiac excitation-contraction coupling.

scholarly journals Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling

2018 ◽  
Vol 122 (1) ◽  
pp. 167-183 ◽  
Author(s):  
Joshua Mayourian ◽  
Delaine K. Ceholski ◽  
David M. Gonzalez ◽  
Timothy J. Cashman ◽  
Susmita Sahoo ◽  
...  
Keyword(s):  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Cardiac Excitation

scholarly journals Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias

2020 ◽  
Vol 11 ◽  
Author(s):  
Hamish M. Aitken-Buck ◽  
Julia Krause ◽  
Tanja Zeller ◽  
Peter P. Jones ◽  
Regis R. Lamberts
Keyword(s):  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Cardiac Excitation ◽  
Long Chain

scholarly journals Use of Rapamycin Reveals Evidence of the Physiological Roles of FKBP12 and FKBP12.6 In Cardiac Excitation-Contraction Coupling

2010 ◽  
Vol 98 (3) ◽  
pp. 299a-300a
Author(s):  
Elena Galfrè ◽  
Elisa Venturi ◽  
Samatha J. Pitt ◽  
Mano Sitsapesan ◽  
Rebecca Sitsapesan ◽  
...  
Keyword(s):  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Cardiac Excitation
Sign in / Sign up

Export Citation Format

Share Document