Disorders of purine biosynthesis metabolism

2021 ◽  
Author(s):  
Joseph P. Dewulf ◽  
Sandrine Marie ◽  
Marie-Cécile Nassogne
Keyword(s):  
Purine Biosynthesis

scholarly journals Inosine in Biology and Disease

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 600
Author(s):  
Sundaramoorthy Srinivasan ◽  
Adrian Gabriel Torres ◽  
Lluís Ribas de Pouplana
Keyword(s):  
Human Health ◽  
Purine Biosynthesis ◽  
Messenger Rnas ◽  
Transfer Rnas ◽  
Functional Roles ◽  
Codon Recognition ◽  
Wobble Position ◽  
Biosynthesis Gene ◽  
The Stability ◽  
Cell Signaling Pathways

The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs (mRNAs). At the wobble position of tRNA anticodons, inosine profoundly modifies codon recognition, while in mRNA, inosines can modify the sequence of the translated polypeptide or modulate the stability, localization, and splicing of transcripts. Inosine is also found in non-coding and exogenous RNAs, where it plays key structural and functional roles. In addition, molecular inosine is an important secondary metabolite in purine metabolism that also acts as a molecular messenger in cell signaling pathways. Here, we review the functional roles of inosine in biology and their connections to human health.

scholarly journals Carbocyclic substrates for de novo purine biosynthesis.

1991 ◽  
Vol 266 (25) ◽  
pp. 16699-16702
Author(s):  
D.S. Liu ◽  
C.A. Caperelli
Keyword(s):  
De Novo ◽  
Purine Biosynthesis ◽  
De Novo Purine Biosynthesis

scholarly journals Stimulation of Hepatic Purine Biosynthesis by Orotic Acid

1965 ◽  
Vol 240 (11) ◽  
pp. 4398-4405
Author(s):  
H.G. Windmueller ◽  
Albert E. Spaeth
Keyword(s):  
Orotic Acid ◽  
Purine Biosynthesis ◽  
Stimulation Of

scholarly journals Purine Biosynthesis de Novo in Mouse Tissues and a Mouse Tumor

1959 ◽  
Vol 234 (9) ◽  
pp. 2364-2368 ◽  
Author(s):  
J. Frank Henderson ◽  
G.A. LePage
Keyword(s):  
De Novo ◽  
Purine Biosynthesis ◽  
Mouse Tumor ◽  
Mouse Tissues

Observations on the site of 6-chloropurine-induced inhibition of purine biosynthesis

1962 ◽  
Vol 55 (1-2) ◽  
pp. 214-216 ◽  
Author(s):  
Alan C. Sartorelli ◽  
Barbara A. Booth
Keyword(s):  
Purine Biosynthesis
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