<b>Objective</b><b></b>
<p>We
aimed to explore the associations between type 2 diabetes onset age and cardiovascular
disease (CVD) and all-cause mortality in Chinese population.</p>
<p><b>Research design and methods</b></p>
<p>This study included 101,080 participants free of prevalent
diabetes and CVD at baseline from the Kailuan study. All participants were
followed biennially until December 31, 2017. A total of 11,384 participants
were diagnosed as type 2 diabetes during follow-up. For each case, one control
was randomly selected matched for age (±1 years) and sex. The final analysis
comprised 10,777 case-control pairs. Weighted Cox regression models were used
to evaluate the average hazard ratios (AHRs) and 95% confidence intervals (CIs)
of incident CVD and all-cause mortality among patients with new-onset type 2
diabetes <i>versus </i>controls across age
groups.</p>
<p><b>Results</b><b></b></p>
<p>During a median follow-up
of 5.57 years, 1794 incident events (907 CVD events, of which were 725 strokes,
and 887 deaths) occurred. After adjustment for potential confounders, participants
with type 2
diabetes diagnosed at age < 45 years had the highest risks of CVD and
all-cause mortality relative to the matched controls, with AHRs of 3.21 (95% CI
1.18–8.72) for CVD, 2.99 (95% CI 1.01–9.17) for stroke, and 4.79 (95% CI
1.95–11.76) for all-cause mortality. The risks gradually attenuated with each
decade increase in type 2 diabetes onset age. </p>
<p><b>Conclusions</b><b></b></p>
<p>The relative risks of CVD
and all-cause mortality differed across type 2 diabetes onset age groups, and
the associations were more evident in younger-onset type 2 diabetes. </p>
Early smoking-onset age and risk of cardiovascular disease and mortality
