Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio

Drug Metabolite ◽

Physiologically Based ◽

Vitro Data ◽

The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Drug Metabolism and Disposition ◽

10.1124/dmd.116.071639 ◽

2016 ◽

Vol 44 (10) ◽

pp. 1569-1578 ◽

Cited By ~ 11

Author(s):

H. Q. Nguyen ◽

E. Callegari ◽

R. S. Obach

Keyword(s):

Poor Metabolizers ◽

Drug Metabolite ◽

Physiologically Based ◽

Vitro Data ◽

Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104661 ◽

2020 ◽

Vol 114 ◽

pp. 104661

Author(s):

Chi Zhang ◽

Qiang Zhang ◽

Jin Li ◽

Lin Yu ◽

Fengxiang Li ◽

...

Keyword(s):

Heparg Cells ◽

Physiologically Based ◽

Acetaminophen Hepatotoxicity ◽

Vitro Data ◽

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Cited By ~ 42

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Modeling Approaches ◽

Drug Concentrations ◽

Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Cited By ~ 18

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

Toxicological Sciences ◽

10.1093/toxsci/kfz042 ◽

2019 ◽

Vol 169 (2) ◽

pp. 365-379 ◽

Cited By ~ 9

Author(s):

Gina Song ◽

Marjory Moreau ◽

Alina Efremenko ◽

Brian G Lake ◽

Huali Wu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Age Related ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Vitro Data ◽

Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Cited By ~ 7

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Human Metabolism ◽

Blood Concentrations ◽

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Cited By ~ 22

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Human Metabolism ◽

Blood Concentrations ◽

Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Inhalation Toxicology ◽

10.1080/08958378.2020.1715513 ◽

2019 ◽

Vol 31 (13-14) ◽

pp. 468-483 ◽

Cited By ~ 2

Author(s):

Harvey J. Clewell ◽

Jerry L. Campbell ◽

Cynthia Van Landingham ◽

Allison Franzen ◽

Miyoung Yoon ◽

...

Keyword(s):

Risk Assessment ◽

In Vitro Metabolism ◽

Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

Inhalation Toxicology ◽

10.1080/08958378.2020.1817199 ◽

2020 ◽

Vol 32 (9-10) ◽

pp. 369-371

Author(s):

H. J. Clewell ◽

J. L. Campbell ◽

C. Van Landingham ◽

A. Franzen ◽

M. Yoon ◽

...

Keyword(s):

Risk Assessment ◽

In Vitro Metabolism ◽

Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.12.024 ◽

2018 ◽

Vol 107 (5) ◽

pp. 1330-1341 ◽

Cited By ~ 22

Author(s):

Hitesh S. Purohit ◽

Niraj S. Trasi ◽

Dajun D. Sun ◽

Edwin C.Y. Chow ◽

Hong Wen ◽

...

Keyword(s):

Modeling And Simulation ◽

In Vitro Dissolution ◽

Dissolution Testing ◽

Pharmacokinetic Modeling And Simulation

Physiologically Based ◽

The Impact ◽