Progress Towards an OECD Reporting Framework for Transcriptomics and Metabolomics in Regulatory Toxicology

Based on the experiences of three research groups using and evaluating the Cognitive Interviewing Reporting Framework (CIRF), we draw conclusions about the utility of the CIRF as a guide to creating cognitive testing reports. Authors generally found the CIRF checklist to be usable, and that it led to a more complete description of key steps involved. However, despite the explicit direction by the CIRF to include a full explanation of major steps and features (e.g., research objectives and research design), the three cognitive testing reports tended to simply state what was done, without further justification. Authors varied in their judgments concerning whether the CIRF requires the appropriate level of detail. Overall, we believe that current cognitive interviewing practice will benefit from including, within cognitive testing reports, the 10 categories of information specified by the CIRF. Future use of the CIRF may serve to direct the overall research project from the start, and to further the goal of evaluation of specific cognitive interviewing procedures.

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Evaluating the Cognitive Interviewing Reporting Framework (CIRF) by Rewriting a Dutch Pretesting Report of a European Health Survey Questionnaire *The views expressed in this paper are those of the authors and do not necessarily reflect the policies of Statistics Netherlands.

Methodology ◽

10.1027/1614-2241/a000072 ◽

2013 ◽

Vol 9 (3) ◽

pp. 104-112 ◽

Cited By ~ 2

Author(s):

Rachel Vis-Visschers ◽

Vivian Meertens

Keyword(s):

Health Survey ◽

Cognitive Interviewing ◽

Survey Questionnaire ◽

Reporting Framework ◽

Research Designs ◽

European Health ◽

Original Report ◽

Minimal Standard ◽

Exhaustive List

We used the Cognitive Interviewing Reporting Framework (CIRF) to restructure the report of a pretest on a European health survey questionnaire. This pretest was conducted by the Questionnaire Laboratory of Statistics Netherlands, and the original report was written according to a standard Statistics Netherlands format for pretesting reports. This article contains the rewritten report with highlights from the case study. The authors reflect on the process of rewriting and the usefulness of the CIRF. We conclude that expanded use of the CIRF as a reporting format for articles on cognitive pretests would enhance international comparability, completeness, and uniformity of research designs, terminology, and reporting. A limitation of the CIRF is that it does not provide an exhaustive list of items that could be included in a report, but it is more a “minimal standard”: that is a report on how a cognitive pretest was conducted should at least contain a description of the CIRF items.

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Impacts and Benefits of COAG Reforms: Reporting Framework

SSRN Electronic Journal ◽

10.2139/ssrn.2006019 ◽

2010 ◽

Cited By ~ 2

Author(s):

Productivity Commission

Keyword(s):

Reporting Framework

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The Adoption of the Integrated Reporting Framework: A Perspective of Supervisory Board Members on the Drivers and Benefits

SSRN Electronic Journal ◽

10.2139/ssrn.3454615 ◽

2019 ◽

Author(s):

Brigitte de Graaff ◽

H. B. A. Steens

Keyword(s):

Supervisory Board ◽

Board Members ◽

Integrated Reporting ◽

Reporting Framework

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Proof of Concept: The Use of Whole-Slide Images (WSI) for Peer Review of Tissues on Routine Regulatory Toxicology Studies

Toxicologic Pathology ◽

10.1177/0192623320983252 ◽

2021 ◽

pp. 019262332098325

Author(s):

Alys E. Bradley ◽

Maurice G. Cary ◽

Kaori Isobe ◽

Stuart Naylor ◽

Stephen Drew

Keyword(s):

Peer Review ◽

Proof Of Concept ◽

Regulatory Toxicology ◽

Glass Slides ◽

Microscopic Findings ◽

Slight Discrepancy ◽

Whole Slide Images ◽

Diagnostic Discrepancies

This Proof of Concept (POC) study was to assess whether assessment of whole slide images (WSI) of the 2 target tissues for a contemporaneous peer review can elicit concordant results to the findings generated by the Study Pathologist from the glass slides. Well-focused WSI of liver and spleen from 4 groups of mice, that had previously been diagnosed to be the target tissues by an experienced veterinary toxicologic pathologist examining glass slides, were independently reviewed by 3 veterinary pathologists with varying experience in assessment of WSIs. Diagnostic discrepancies were then reviewed by an experienced adjudicating pathologist. Assessment of microscopic findings using WSI showed concordance with the glass slides, with only slight discrepancy in severity grades noted. None of the lesions recorded by the Study pathologist were “missed” and no lesions were added by the pathologists evaluating WSIs, thus demonstrating equivalence of the WSI to glass slides for this study.

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Letter to the Editor in Response to Forristal et al.: Improving the Quality of Risk Assessments in Canada Using a Principle-Based Approach, Regulatory Toxicology and Pharmacology 50 (2008) 336–344

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2008.12.001 ◽

2009 ◽

Vol 53 (2) ◽

pp. 156-157

Author(s):

Bette Meek

Keyword(s):

Risk Assessments ◽

Regulatory Toxicology ◽

Letter To The Editor

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Relevance of Animal Studies in Regulatory Toxicology: Current Approaches and Future Opportunities

Alternatives to Laboratory Animals ◽

10.1177/026119299602400208 ◽

1996 ◽

Vol 24 (2) ◽

pp. 173-178

Author(s):

Johannes J.M. van de Sandt ◽

Victor J. Feron

Keyword(s):

Risk Assessment ◽

Risk Evaluation ◽

Animal Studies ◽

Regulatory Toxicology ◽

Animal Test ◽

Toxicity Studies ◽

Increasing Knowledge ◽

Scientific Value

With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach, in order to increase the relevance of each animal test conducted. The development of new types of toxicity studies and their application in risk evaluation are also described.

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