Mortality and morbidity rates of patients older and younger than 75 years with acute myocardial infarction treated with intravenous streptokinase

1987 ◽  
Vol 59 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Allan S. Lew ◽  
Hanoch Hod ◽  
Bojan Cercek ◽  
Prediman K. Shah ◽  
William Ganz
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Intravenous Streptokinase ◽  
Mortality And Morbidity

scholarly journals Peripheral Levels of EPCs, T Cells, and Macrophages’ as Possible Predictive Biomarkers of Acute Myocardial Infarction

2020 ◽  
Author(s):  
Amankeldi Salybekov ◽  
Katsuaki Sakai ◽  
Makoto Natsumeda ◽  
Kosit Vorateera ◽  
Shuzo Kobayashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cells ◽  
Cd8 T Cells ◽  
Immune Cell ◽  
Temporal Dynamics ◽  
Predictive Biomarkers ◽  
Mortality And Morbidity ◽  
Patients With Diabetes ◽  
Functionally Impaired

Abstract Acute myocardial infarction (AMI), with a very relevant global disease burden, remains the major mortality and morbidity cause among all cardiovascular diseases. Patient prognosis is strictly dependent on early diagnosis and the adoption of adequate interventions. AMI diagnosis requires constant optimization, particularly considering the individuals at higher risk (or more vulnerable to worse outcomes) such as patients with diabetes mellitus and atherosclerosis. Herein, we investigated the levels of peripheral blood EPCs and immune cell-subsets from myeloid and lymphoid lineages, as well as their temporal dynamics, in the quest for new prognostic biomarkers of AMI. We collected blood from 18 hospitalized patients (days 3 and 7 after AMI onset) and 16 healthy volunteers, and resolved their circulating PBMC populations via flow cytometry. Overall, our data demonstrate a significant decrease in peripheral EPCs and CD8+ T cells, three days following an AMI. EPCs appear to be functionally impaired in AMI patients, and their circulating numbers associate with cardiac vessel lesions. Furthermore, CD8+ T cells (and even M1-macrophages) in the periphery, in combination with the classical laboratory determinations, may serve as high accuracy biomarkers of AMI, potentially aiding to prevent worse AMI outcomes.

A double-blind randomized multicenter dose-ranging trial of intravenous streptokinase in acute myocardial infarction

1990 ◽  
Vol 65 (3) ◽  
pp. 119-123 ◽  
Author(s):  
A.Jacob Six ◽  
Hans W. Louwerenburg ◽  
Reinier Braams ◽  
Karel Mechelse ◽  
Willem L. Mosterd ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Double Blind ◽  
Intravenous Streptokinase ◽  
Dose Ranging

Acute myocardial infarction-related coronary artery residual narrowing after intravenous streptokinase: Relationship with previous coronary symptoms

1989 ◽  
Vol 118 (5) ◽  
pp. 888-892 ◽  
Author(s):  
Ricardo Aquiles Sarmiento ◽  
Julio Jorge Blüguermann ◽  
Renato C.A.González Mora ◽  
Miguel Angel Riccitelli ◽  
Carlos Alberto Bertolasi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Intravenous Streptokinase

scholarly journals High dose intravenous streptokinase in acute myocardial infarction--short and long term prognosis.

Heart ◽  
1986 ◽  
Vol 55 (3) ◽  
pp. 231-239 ◽  
Author(s):  
B A MacLennan ◽  
A McMaster ◽  
S W Webb ◽  
M M Khan ◽  
A A Adgey
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
High Dose ◽  
Intravenous Streptokinase ◽  
Short And Long Term ◽  
Long Term Prognosis

FIBRINOGEN DOSAGE AS A SYSTEMIC MARKER OF UNSUCCESSFUL INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1987 ◽  
Author(s):  
Ch Col-De Beys ◽  
E Lavenne-Pardonge ◽  
M Moriau ◽  
J Renkin ◽  
J Col
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Occlusion ◽  
Plasminogen Activators ◽  
Clot Lysis ◽  
Thrombin Time ◽  
Intravenous Streptokinase ◽  
Method Of Determination ◽  
Arterial Recanalization

Whether failure to timely recanalize coronary artery with intravenous streptokinase (SK) is related to inadequate fibrinolysis remains controversial. Since coagulation might also interfere with the course of clot lysis, this relation was investigated in 27 patients (pts) pretreated with heparin (10.000 IU bolus). 500.000 to 1.500.000 IU SK were infused in 45 min, 160 ± 60 min after the onset of infarct.Angiographic control, performed 219 ± 199 min after SK, showed persistent coronary occlusion in 5 pts (0CC) and patency in 22 (PAT), unrelated to SK dosage. One to 3 hours post SK, fibrinogen (Fg) (Clauss Method) was undetectable in all 22 PAT and 4/5 0CC. However, Fg (and clottable breakdown products) assessed by Gram's method* was detected in all 5 OCC and 3/22 PAT (164 ± 89 VS 13 ± 38 mg %, p < 0.005). Prolongation of thrombin time (neutralized with protamine) was limited in OCC, compared to PAT (59 ± 6 VS 96 ± 11 sec, p < 0.005), supporting the hypothesis of the presence of clottable material in OCC. These results were accompanied by slight differences of ELT (< 20 min in 2/5 OCC VS 21/22 PAT) and non significant differences in plasminogen (1.78 ± 1 VS 2.18 ± 1.1 mg/dl ; NS), α2 antiplasmin (1.7 ± 1.7 VS 3.9 ± 6.9 % ; NS), plasmin (12 ± 4 VS 16 ± 11 mm2 ; NS) and plasminogen activators (95 ± 41 VS 105 ± 23 mm2 ; NS).Conclusion : at similar systemic lytic activity induced by SK, failure of arterial recanalization was associated wih an apparent incomplete fibrinogenolysis (and fibrinolysis) in 20 % of the patients.*Gram H.C. - A new method of determination of the fibrin percent in blood and plasma - J Biol Chem 49 : 279 - 295 (1921)mean ± SD

Coronary thrombolysis by intravenous streptokinase in acute myocardial infarction: Acute and follow-up studies

1984 ◽  
Vol 53 (6) ◽  
pp. 655-661 ◽  
Author(s):  
James F. Spann ◽  
Sol Sherry ◽  
Blase A. Carabello ◽  
Barry S. Denenberg ◽  
Richard H. Mann ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Intravenous Streptokinase ◽  
Coronary Thrombolysis ◽  
Follow Up Studies
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