The effect of high molecular phospholipase A2 inhibitors on 3T6 fibroblast proliferation

2001 ◽  
Vol 61 (7) ◽  
pp. 811-816 ◽  
Author(s):  
Teresa Sanchez ◽  
Juan J. Moreno
Keyword(s):  
Phospholipase A2 ◽  
Fibroblast Proliferation ◽  
Phospholipase A2 Inhibitors

Synthesis of Spongidine A, D and Petrosaspongiolide L Methyl Ester Using Pyridine C-H Functionalization

2019 ◽  
Author(s):  
Florian Bartels ◽  
Manuela Weber ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Methyl Ester ◽  
Hydrogen Atom ◽  
Phospholipase A2 ◽  
Late Stage ◽  
Hydrogen Atom Transfer ◽  
Ring System ◽  
Tetracyclic Core ◽  
Intramolecular Hydrogen ◽  
Phospholipase A2 Inhibitors

<div>An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.</div>

A versatile synthon approach to the preparation of some phospholipase A2 inhibitors

1992 ◽  
Vol 33 (4) ◽  
pp. 547-550 ◽  
Author(s):  
JMC Golec ◽  
C.J.R. Hedgecock ◽  
P.D. Kennewell
Keyword(s):  
Phospholipase A2 ◽  
Phospholipase A2 Inhibitors
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