GABAA and GABAB receptors modulating basal and footshock-induced nitric oxide releases in rat prefrontal cortex

2000 ◽  
Vol 872 (1-2) ◽  
pp. 266-270 ◽  
Author(s):  
Yuta Ishizuka ◽  
Yasushi Ishida ◽  
Qing-Hua Jin ◽  
Yoshio Mitsuyama ◽  
Hiroshi Kannan
Keyword(s):  
Nitric Oxide ◽  
Prefrontal Cortex ◽  
Gabab Receptors ◽  
Gabaa And Gabab Receptors

scholarly journals Evidence for involvement of nitric oxide and GABAB receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex

2012 ◽  
Vol 63 (4) ◽  
pp. 575-581 ◽  
Author(s):  
Nicole L. Roenker ◽  
Gary A. Gudelsky ◽  
Rebecca Ahlbrand ◽  
Paul S. Horn ◽  
Neil M. Richtand
Keyword(s):  
Nitric Oxide ◽  
Prefrontal Cortex ◽  
Gabab Receptors ◽  
Mk 801

scholarly journals Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 709
Author(s):  
Bradley M. Roberts ◽  
Emanuel F. Lopes ◽  
Stephanie J. Cragg
Keyword(s):  
Gabab Receptors ◽  
Striatal Dopamine ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Short Term Plasticity ◽  
Psychomotor Disorders ◽  
Gabaa And Gabab Receptors ◽  
Uptake Transporters ◽  
Gabaergic Modulation ◽  
Da Release

Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence indicating that DA output is inhibited by striatal γ-aminobutyric acid (GABA) acting via GABAA and GABAB receptors. We review evidence supporting the localisation of GABAA and GABAB receptors to DA axons, as well as the identity of the striatal sources of GABA that likely contribute to GABAergic modulation of DA release. We discuss emerging data outlining the mechanisms through which GABAA and GABAB receptors inhibit the amplitude as well as modulate the short-term plasticity of DA release. Furthermore, we highlight recent data showing that DA release is governed by plasma membrane GABA uptake transporters on striatal astrocytes, which determine ambient striatal GABA tone and, by extension, the tonic inhibition of DA release. Finally, we discuss how the regulation of striatal GABA-DA interactions represents an axis for dysfunction in psychomotor disorders associated with dysregulated DA signalling, including Parkinson’s disease, and could be a novel therapeutic target for drugs to modify striatal DA output.

scholarly journals Inhibition of Nigrostriatal Dopamine Release by Striatal GABAA and GABAB Receptors

2018 ◽  
Vol 39 (6) ◽  
pp. 1058-1065 ◽  
Author(s):  
Emanuel F. Lopes ◽  
Bradley M. Roberts ◽  
Ruth E. Siddorn ◽  
Michael A. Clements ◽  
Stephanie J. Cragg
Keyword(s):  
Dopamine Release ◽  
Gabab Receptors ◽  
Nigrostriatal Dopamine ◽  
Gabaa And Gabab Receptors

Differential subcellular and subsynaptic distribution of GABAA and GABAB receptors in the monkey subthalamic nucleus

Neuroscience ◽  
2004 ◽  
Vol 127 (3) ◽  
pp. 709-721 ◽  
Author(s):  
A Galvan ◽  
A Charara ◽  
J.-F Pare ◽  
A.I Levey ◽  
Y Smith
Keyword(s):  
Subthalamic Nucleus ◽  
Gabab Receptors ◽  
Gabaa And Gabab Receptors
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