Operant behavior during sessions of intravenous cocaine infusion is necessary and sufficient for phasic firing of single nucleus accumbens neurons

1997 ◽  
Vol 757 (2) ◽  
pp. 280-284 ◽  
Author(s):  
Laura L Peoples ◽  
Anthony J Uzwiak ◽  
Fred Gee ◽  
Mark O West
Keyword(s):  
Nucleus Accumbens ◽  
Operant Behavior ◽  
Single Nucleus ◽  
Necessary And Sufficient ◽  
Cocaine Infusion ◽  
Intravenous Cocaine

scholarly journals An endogenous opioid circuit determines state-dependent appetitive behavior

2021 ◽  
Author(s):  
Daniel C. Castro ◽  
Corinna S. Oswell ◽  
Eric T. Zhang ◽  
Christian E. Pedersen ◽  
Sean C. Piantadosi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Peptide ◽  
Behavioral State ◽  
Endogenous Opioid ◽  
Mu Opioid ◽  
Peptide Receptor ◽  
Appetitive Behavior ◽  
State Dependent ◽  
Selective Modulation ◽  
Necessary And Sufficient

AbstractMu-opioid peptide receptor (MOPR) stimulation alters respiration, analgesia, and reward behavior, and can induce addiction and drug overdose. Despite its evident importance, the endogenous mechanisms for MOPR regulation of appetitive behavior have remained unknown. Here we report that endogenous MOPR regulation of appetitive behavior in mice acts through a specific dorsal raphe to nucleus accumbens projection. MOPR-mediated inhibition of raphe terminals is necessary and sufficient to determine appetitive behavioral state while select enkephalin-containing NAc ensembles are engaged prior to reward consumption, suggesting that local enkephalin release is the source of endogenous MOPR ligand. Selective modulation of NAc enkephalin neurons and CRISPR-Cas9-mediated disruption of enkephalin substantiate this finding. These results isolate a fundamental endogenous opioid circuit for state-dependent appetitive behavior and suggest alternative mechanisms for opiate modulation of reward.

scholarly journals HCN2 in cholinergic interneurons of the nucleus accumbens mediates reward response

2021 ◽  
Author(s):  
Jinah Lee ◽  
Marina Weinberger ◽  
Yuki Kawahara ◽  
Jia Cheng ◽  
Gali Umscweif ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Cyclic Nucleotide ◽  
Behavioral Response ◽  
Cholinergic Neurons ◽  
Cholinergic Receptors ◽  
Nerve Terminals ◽  
Cholinergic Interneurons ◽  
Gated Channel ◽  
Cocaine Infusion ◽  
Da Release

Cholinergic interneurons (ChIs) of the nucleus accumbens (NAc) are important for mediating the behavioral response to rewarding stimuli. A major role for these cells is to regulate dopamine (DA) transmission by activating cholinergic receptors at local DAergic nerve terminals. However, the mechanisms that enable cholinergic neurons to enhance DA release in response to reward remain unknown. Here we report that the hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) in NAc ChIs mediates an enhancement in DA signaling in response to rewarding stimuli. The HCN current in NAc ChIs and its modulation by DA, as well as the increase in cholinergic efflux by local cocaine infusion were impaired in mice with deletion of HCN2 in cholinergic cells. Enhancement in the DA efflux and signaling in the NAc in response to rewarding stimuli, as well as cocaine conditioning were also dependent on HCN2 in ChIs. These results provide a mechanistic link between the activity of NAc ChIs and reward encoding.

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