Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: A randomized, double-blind single-dose study

1999 ◽  
Vol 66 (6) ◽  
pp. 625-635
Author(s):  
E BREIVIK ◽  
P BARKVOLL ◽  
E SKOVLUND
Keyword(s):  
Single Dose ◽  
Oral Surgery ◽  
Double Blind ◽  
Single Dose Study ◽  
Dose Study

Analgesic Effect of Aspirin, Mefenamic Acid and Their Combination in Post-Operative Oral Surgery Pain

1988 ◽  
Vol 16 (3) ◽  
pp. 167-172 ◽  
Author(s):  
S. Or ◽  
A. Bozkurt
Keyword(s):  
Single Dose ◽  
Pain Relief ◽  
Pain Intensity ◽  
Mefenamic Acid ◽  
Analgesic Effect ◽  
Oral Surgery ◽  
Double Blind ◽  
Single Dose Study ◽  
Analgesic Effects ◽  
Dose Study

A double-blind randomized single dose study of the analgesic effects of 650 mg aspirin, 250 mg mefenamic acid, the combination of 650 mg aspirin and 250 mg mefenamic acid and placebo on 120 patients with pain following oral surgery was conducted. Patients evaluated their pain intensity and extent of pain relief at 1, 2, 3 and 4 h after drug administration. For most parameters, including the sum of the pain intensity differences and the sum of the hourly pain relief scores, each of the drugs was more effective than placebo. Aspirin–mefenamic acid in combination was more effective than both drugs alone, and aspirin and mefenamic acid alone were equally effective for most of the analgesic variables.

scholarly journals Pharmacokinetics, safety and tolerability of L-3-n-butylphthalide tablet after single and multiple oral administrations in healthy Chinese volunteers

2015 ◽  
Vol 51 (3) ◽  
pp. 525-531 ◽  
Author(s):  
Meng Wang ◽  
Quan-ying Zhang ◽  
Wen-yan Hua ◽  
Ming Huang ◽  
Wen-jia Zhou ◽  
...  
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Compartmental Analysis ◽  
Pharmacokinetic Parameters ◽  
Double Blind ◽  
Single Dose Study ◽  
Multiple Dose Study ◽  
Dose Study ◽  
Repeated Doses ◽  
Healthy Chinese

L-3-n-butylphthalide (L-NBP) is a naturally occurring antioxidant, which can be used for the treatment of acute ischemic stroke and vascular dementia. This study evaluated the safety, tolerability and pharmacokinetics of L-NBP tablets in healthy Chinese volunteers. This was a single-center, randomized, double-blind, placebo-controlled, single- and multiple-dose study. Subjects were assigned to receive a single dose of L-NBP tablet at either 80, 160, 320, or 480 mg (n=40), or multiple doses of 160 mg twice daily for 7 days (n=12). Plasma samples were analyzed with LC-MS/MS. Pharmacokinetic parameters of L-NBP were calculated using non-compartmental analysis with WinNonlin software. Statistical analysis was performed using SPSS software. All adverse events (AEs) were mild and of limited duration; AEs in this study occurred less frequently and more mildly than AEs listed for the DL-NBP soft capsule. No serious adverse event (SAE), death or withdrawal from the study was observed. In the single-dose study, Cmax was reached at about 1 h, and the mean t1/2 was approximately 13.76 h. Area under curve (AUC) and Cmax increased with dose escalation, but dose proportionality was not observed over the range of 160 to 480 mg. In the multiple-dose study, the steady-state was reached within 3 days with slight accumulation. In summary, the L-NBP tablet was well tolerated in healthy Chinese subjects. Slight accumulation appeared after repeated doses.

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