Differential diagnosis of amyotrophic lateral sclerosis and similar syndromes

1997 ◽  
Vol 103 (1) ◽  
pp. 168
Author(s):  
B Ishpekova
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Lateral Sclerosis

scholarly journals Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

2018 ◽  
Vol 10 (4) ◽  
pp. 139-144 ◽  
Author(s):  
T. M. Alekseeva ◽  
N. V. Skripchenko ◽  
S. V. Lobzin ◽  
V. S. Demeshonok ◽  
E. A. Yurkina ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Hiv Infection ◽  
Positive Patient ◽  
Hiv Positive ◽  
Genetic Tests ◽  
Lateral Sclerosis

We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is discussed.

Amyotrophic lateral sclerosis and sarcoidosis: A difficult differential diagnosis

2009 ◽  
Vol 11 (4) ◽  
pp. 410-411
Author(s):  
Elena Canali ◽  
Patrizia Sola ◽  
Luca Richeldi ◽  
Paolo Spagnolo ◽  
Gabriele Mora ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Lateral Sclerosis

Comorbidity of Cervical Spondylogenic Myelopathy and Amyotrophic Lateral Sclerosis: When Electromyography Makes the Difference in Diagnosis

2020 ◽  
pp. 1-4
Author(s):  
Maria Claudia Torrieri ◽  
Matteo Monticelli ◽  
Rosario Vasta ◽  
Fabio Cofano ◽  
Marco Ajello ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Clinical Practice ◽  
Predictive Value ◽  
Good Accuracy ◽  
Cervical Cord ◽  
Clinical Progression ◽  
The Difference ◽  
Lateral Sclerosis

Cervical spondylogenic myelopathy (CSM) represents a common differential diagnosis for spinal onset Amyotrophic Lateral Sclerosis (ALS). Identifying occurrence of ALS in patients with CSM may be challenging. We evaluated the accuracy of Awaji criteria in the diagnosis of ALS in a cohort of patients with CSM. We screened all patients attending Turin ALS Center during the 2006–2018 period. We selected only patients for whom cervical cord MRI showed radiological signs of CSM. All patients underwent electromyography (EMG), and Awaji criteria were used for diagnosis of clinically probable ALS. All patients were followed up clinically for at least 6 months, and ALS diagnosis was eventually confirmed according to El-Escorial revised criteria, based on disease progression. Of 2,059 patients screened, in 42 cases, MRI showed signs of CSM; CSM incidence and prevalence risks were 0.16 and 2.04%, respectively. Based on clinical progression, 72.7% of patients were diagnosed as CSM and 27.3% as CSM + ALS. At EMG 6 (18.2%) patients fulfilled the criteria for ALS, 5 of them (83.3%) during clinical follow-up were diagnosed as clinical definite ALS + CSM. Accuracy of Awaji criteria in diagnosing ALS was good (AUC = 0.757, <i>p</i> = 0.03). Sensitivity and specificity of Awaji criteria were, respectively, 55.6 and 95.8%. Positive predictive value was 83.3%, while negative predictive value was 85.2%. CSM-ALS comorbidity is a relatively common problem in clinical practice. To better choose patients who could benefit from surgery, EMG should be performed in CSM patients, due to its good accuracy in recognizing ALS.

scholarly journals Case of aluminium poisoning, with differential diagnosis for amyotrophic lateral sclerosis (als)

2021 ◽  
Author(s):  
Victória Nunes Oliveira ◽  
Mellyssa Cota Elias ◽  
Heloiza Castilhoni Belique ◽  
Gabriel Lima Martins ◽  
Bianca Soares de Sá Peixoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Clinical Presentation ◽  
Neuronal Degeneration ◽  
Axonal Neuropathy ◽  
Cognitive Disorders ◽  
Dietary Supplementation ◽  
Essential Metals ◽  
Lateral Sclerosis

Introduction: Essential metals in high quantities can accumulate and reach toxicity. In the CNS, they lead to neurodegeneration, causing movement and cognitive disorders. Case Report: White man, 59 years, sanitation agent, uses PPE irregularly. For 1 year presented progressive speech disorder, paresis, emaciation, dysphonia, tongue atrophy, limbs fasciculations and abnormal reflexes; normal tonus/ sensibility. Bulbar/limb electroneuromyography and serum dosage of metals in contact were requested, revealing muscles denervation, axonal diffuse polyneuropathy with postganglionic injury and elevated seric Aluminum (Al), (35,7ug/L). The management was work leave, Nortriptyline, and dietary supplementation. It evolved with reduction in seric Al (3,3ug/L); the physical examination remained unaltered. The condition stabilized after treatment. Discussion: Al exposure causes oxidative stress/neurotoxicity, leading to neuronal degeneration. Axonal sensorimotor neuropathy, progressive asthenia, emaciation, fasciculations, aphasia, ataxia, tongue atrophy, and organs injuries can be found. In this case, the clinical presentation differs from ALS because of sensibility commitment and postganglionic alteration, compatible with chronic axonal neuropathy. Conclusion: Although ALS is the most common MND, atypical cases need further investigation to diagnose and treat correctly.

scholarly journals Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Rana Zakaria Ahmed Mohamed ◽  
Haitham Hamdy Salem ◽  
Hossam Moussa El-Sayed Sakr ◽  
Hossam-Eldin Mahmoud Afifi ◽  
Ahmed Mohammed Elsadek ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Neurodegenerative Disorders ◽  
Peripheral Nerves ◽  
Radiological Criteria ◽  
Lateral Sclerosis

Abstract Background Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS). There are many clinical and radiological criteria to diagnose amyotrophic lateral sclerosis and to differentiate it from other motor neuron disease and neurodegenerative disorders. Neuro-sonography is one of the easily applied tools to diagnose and differentiate ALS. ALS diagnosis is delayed up to 3 years according to some authors due to the wide differential diagnosis, with cervical degeneration being a common misdiagnosis. The objective of this study was to evaluate the role of neuro-sonography in diagnosis and differentiation of amyotrophic lateral sclerosis from other causes of progressive mixed upper and lower motor neuron lesion. Results A total neuro-sonography score at a cut-off point (≤ 127) predicted patients with ALS, with good (85%) accuracy, sensitivity = 73% and specificity = 83% (p < 0.01) and Lt median arm score at a cut-off point (≤ 6) predicted patients with ALS, with good (88%) accuracy, sensitivity = 86% and specificity = 86% (p < 0.01) and the median nerve at the arm level was the most sensitive and specific nerve to predict patients with ALS. Conclusion Neuro-sonography of peripheral nerves is a recent, noninvasive, accessible technique that can be used in early diagnosis of ALS.

scholarly journals Neurological disease or conversion disorder? Important aspects of differential diagnosis - psychiatric and psychotherapeutic perspective. Case report

2019 ◽  
Vol 20 (1) ◽  
pp. 9-20
Author(s):  
Sara Tomczak ◽  
Hanna Gorejko ◽  
Wiktor Dróżdż
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Case Report ◽  
Neurological Disease ◽  
Disease Process ◽  
Diagnostic Methods ◽  
Diagnostic Process ◽  
Psychotherapeutic Treatment ◽  
Conversion Disorders ◽  
Lateral Sclerosis

Abstract Introduction: Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with undetermined etiology. Due to diverse symptomatology, it requires a thorough differential diagnosis, with consideration of conversion disorders. The presented thesis describes a case of a young man hospitalized in the Department of Psychiatry in order to verify the possible psychogenic basis of his symptoms, which previously were considered to be a manifestation of neurological disease with an unfavorable prognosis. Aim: The aim of the thesis is to raise the issue of a multidisciplinary approach to diagnostic process in medicine, as well as taking into account the legitimacy of including psychiatrists, psychologists, and psychotherapists in diagnostic teams. Case study: We present a case report of a man who has been experiencing progressive feeling and walking problems for the past several years, which originally suggested a neurological or rheumatological disease. Earlier observations and medical tests had led to a diagnosis of amyotrophic lateral sclerosis. After several years, the diagnosis was excluded, and the patient was referred to the Department of Psychiatry to determine the possible psychogenic basis of his symptoms. Diagnostic methods used during the patient’s hospitalization confirmed the conversational nature of his symptoms, and both pharmacological and psychotherapeutic treatment caused reduction of severity of his symptoms and allowed him for a gradual return to independent functioning. Conclusion: Analysis of the collected data, including patient’s life history and a course of his treatment, indicates the validity of a holistic approach to medical problems, which implies the inclusion of specialists in the field of psychiatry, psychology, as well as psychotherapists in diagnostic teams. Such a multidimensional view of the patient and the source of his symptoms may allow for faster diagnosis and may also contribute to reducing the risk of making mistakes such as an incorrect assessment of factors triggering the disease process.

scholarly journals Serum-based differentiation between multiple sclerosis and amyotrophic lateral sclerosis by Random Forest classification of FTIR spectra

The Analyst ◽  
2019 ◽  
Vol 144 (15) ◽  
pp. 4647-4652 ◽  
Author(s):  
Youssef El Khoury ◽  
Nicolas Collongues ◽  
Jérôme De Sèze ◽  
Vildan Gulsari ◽  
Christine Patte-Mensah ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Differential Diagnosis ◽  
Random Forest ◽  
Serum Samples ◽  
Random Forest Classification ◽  
Forest Classification ◽  
Discrimination Rate ◽  
Lateral Sclerosis

The differential diagnosis of multiple sclerosis and amyotrophic lateral sclerosis is challenging. Random forest classification of infrared spectra of serum samples offers a promising discrimination rate between the two diseases.

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