scholarly journals Both proline-rich sequences in the TH region of Bruton's tyrosine kinase stabilize intermolecular interactions with the SH3 domain

FEBS Letters ◽  
2001 ◽  
Vol 508 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Henrik Hansson ◽  
C.I.Edvard Smith ◽  
Torleif Härd
Keyword(s):  
Tyrosine Kinase ◽  
Intermolecular Interactions ◽  
Sh3 Domain ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

scholarly journals Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase

FEBS Letters ◽  
2001 ◽  
Vol 489 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Henrik Hansson ◽  
Michael P Okoh ◽  
C.I.Edvard Smith ◽  
Mauno Vihinen ◽  
Torleif Härd
Keyword(s):  
Tyrosine Kinase ◽  
Intermolecular Interactions ◽  
Sh3 Domain ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

scholarly journals ANKRD54 preferentially selects Bruton’s Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174909 ◽  
Author(s):  
Manuela O. Gustafsson ◽  
Dara K. Mohammad ◽  
Erkko Ylösmäki ◽  
Hyunseok Choi ◽  
Subhash Shrestha ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Sh3 Domain ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Src Homology 3 ◽  
Src Homology

scholarly journals The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 ◽  
Vol 182 (2) ◽  
pp. 611-615 ◽  
Author(s):  
G O Cory ◽  
R C Lovering ◽  
S Hinshelwood ◽  
L MacCarthy-Morrogh ◽  
R J Levinsky ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
B Cell ◽  
Cell Receptor ◽  
Sh3 Domain ◽  
Protein Product ◽  
B Cell Receptor ◽  
Bruton’S Tyrosine Kinase ◽  
B Cell Differentiation ◽  
Receptor Stimulation ◽  
Bruton's Tyrosine Kinase

X-linked agammaglobulinemia, a B cell immunodeficiency, is caused by mutations in the Bruton's tyrosine kinase (Btk) gene. The absence of a functional Btk protein leads to a failure of B cell differentiation and antibody production. B cell receptor stimulation leads to the phosphorylation of the Btk protein and it is, therefore, likely that Btk is involved in B cell receptor signaling. As a nonreceptor tyrosine kinase, Btk is likely to interact with several proteins within the context of a signal transduction pathway. To understand such interactions, we have generated glutathione S-transferase fusion proteins corresponding to different domains of the human Btk protein. We have identified a 120-kD protein present in human B cells as being bound by the SH3 domain of Btk and which, after B cell receptor stimulation, is one of the major substrates of tyrosine phosphorylation. We have shown that this 120-kD protein is the protein product of c-cbl, a protooncogene, which is known to be phosphorylated in response to T cell receptor stimulation and to interact with several other tyrosine kinases. Association of the SH3 domain of Btk with p120cbl provides evidence for an analogous role for p120cbl in B cell signaling pathways. The p120cbl protein is the first identified ligand of the Btk SH3 domain.

Solution Structure of the SH3 Domain from Bruton's Tyrosine Kinase†,‡

Biochemistry ◽  
1998 ◽  
Vol 37 (9) ◽  
pp. 2912-2924 ◽  
Author(s):  
Henrik Hansson ◽  
Pekka T. Mattsson ◽  
Peter Allard ◽  
Pekka Haapaniemi ◽  
Mauno Vihinen ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Solution Structure ◽  
Sh3 Domain ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase

Stability and folding of the SH3 domain of bruton's tyrosine kinase

1996 ◽  
Vol 26 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Ya-Juan Chen ◽  
Shih-Chieh Lin ◽  
Shiou-Ru Tzeng ◽  
Himatkumar V. Patel ◽  
Ping-Chiang Lyu ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Sh3 Domain ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase
Sign in / Sign up

Export Citation Format

Share Document