Hypertension is a frequent co-morbidity in patients with Barrett's esophagus or reflux esophagitis but not in nonulcer dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A421-A421
Author(s):  
S GUDLAUGSDOTTIR ◽  
J WILSON ◽  
W VERSCHUREN ◽  
J DEES ◽  
T STIJNEN
2001 ◽  
Vol 120 (5) ◽  
pp. A421
Author(s):  
Sunna Gudlaugsdottir ◽  
John Hp Wilson ◽  
Wm Monique Verschuren ◽  
Jan Dees ◽  
Theo Stijnen

2013 ◽  
Vol 144 (5) ◽  
pp. S-1064
Author(s):  
Thai H. Pham ◽  
David H. Wang ◽  
Robert M. Genta ◽  
Rhonda F. Souza ◽  
Stuart J. Spechler

2002 ◽  
Vol 13 (6) ◽  
pp. 369-375 ◽  
Author(s):  
Sunna Gudlaugsdottir ◽  
W.M.Monique Verschuren ◽  
Jan Dees ◽  
Theo Stijnen ◽  
J.H.Paul Wilson

2005 ◽  
Vol 100 (2) ◽  
pp. 499-499 ◽  
Author(s):  
Julio Rafael Mariano da Rocha ◽  
Ivan Cecconello ◽  
Ulysses Ribeiro ◽  
Joaquim Gama-Rodrigues

2018 ◽  
Vol 19 (7) ◽  
pp. 2033 ◽  
Author(s):  
Jolanta Majka ◽  
Mateusz Wierdak ◽  
Iwona Brzozowska ◽  
Marcin Magierowski ◽  
Aleksandra Szlachcic ◽  
...  

Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This “sleep” hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This indoleamine can protect the organs against a variety of damaging agents via multiple signaling. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. Since both of these condition are also identified as major risk factors for esophageal carcinoma, we provide some experimental and clinical evidence that supplementation therapy with melatonin could be useful in esophageal injury by protecting various animal models and patients with GERD from erosions, Barrett’s esophagus and neoplasia. The physiological aspects of the synthesis and release of this indoleamine in the gut, including its release into portal circulation and liver uptake is examined. The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed.


2009 ◽  
Vol 136 (5) ◽  
pp. A-494
Author(s):  
Peter A. Bampton ◽  
Ann C. Schloithe ◽  
Helen Lewis ◽  
Jeff A. Bull ◽  
Jodie Oliver ◽  
...  

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