NONULCER DYSPEPSIA

Objectives: To determine the frequency of nonulcer dyspepsia in patientspresenting with the peptic ulcer like symptoms and to determine the effect of H. pylori eradicationon dyspeptic symptoms and the effect of six weeks trial of proton pump inhibitor as treatmentmeasure. Study design: Cross-sectional study. Setting: Combined Military hospital Quetta,Department of medicine. Period: Six months from Oct, till March 2009. Subjects and Methods:Patients coming to medicine department with complaints of dyspepsia. Results: Total no ofpatients were 145 out of which male were 90 while 55 were females. The mean age was 29.68+ 4.53. These subjects were given H pylori eradication therapy and response was graded aspatients responded or no response. 89 subjects (61.4%) responded to H pylori eradicationtreatment while 56 subjects (38.6%) showed no symptomatic benefit. Non responder toeradication i.e., 37 males and 36 females were given further six week treatment with omeprazole,and subjective response to treatment was graded as complete resolution found in 31 patients (21.4% ), while partial resolution was present in 15 patients (10.3%). 07 patients (4.8%) showedno improvement while 03 patients (2.1%) showed worsening of symptoms. Conclusions: Theprevalence of non-ulcer dyspepsia is high among symptomatic individuals. The response toH pylori eradication was significant. Non responders also showed considerable symptomaticbenefit with PPI. Therefore, individuals with recurrent dyspeptic symptoms should be given trialof H. pylori eradication.

Serum Prolidase Activity, Oxidant and Antioxidant Status in Nonulcer Dyspepsia and Healthy Volunteers

Helicobacter pylori (H. pylori) infection is associated with increased oxidative stress and serum prolidase activity (SPA) in many diseases. We aimed to observe SPA and oxidative stress in nonulcer dyspepsia (NUD) infected with and without H. pylori among eastern Indians. 106 patients with H. pylori positive NUD, 82 patients with H. pylori negative NUD, and 50 healthy individuals were selected. SPA, total antioxidant capacity (TAOC), and total oxidant status (TOS) were measured with the use of spectrophotometer and an automated measurement method. SPA, TOS, and oxidative stress index (OSI) were significantly higher in patients with H. pylori positive than H. pylori negative NUD and healthy individuals (all ), whereas TAOC was significantly lower (). Nonsignificant, increased SPA ( value = 0.6083) and decreased TAOC ( value = 0.1186) were observed in patients with H. pylori negative NUD than healthy individuals, while increased TOS and OSI were significant (). Weak, nonsignificant correlations were observed between serum prolidase activity and TAOC, TOS, and OSI in H. pylori positive cases. Thus, increased SPA along with increased oxidative stress was observed, which seem to be closely associated with H. pylori infection. SPA and oxidative stress seem to be used as biomarkers for H. pylori infection in NUD.