Impaired gastric ulcer healing in diabetic rats: Role of angiogenesis, growth factors, heat shock protein and proinflammatory cytokines

2003 ◽  
Vol 124 (4) ◽  
pp. A448
Author(s):  
Peter Konturek ◽  
Tomasz Bizozowski auKarolina^Bazela ◽  
Igor Harsch ◽  
Vitaly Kukharsky ◽  
Wieslaw Pawlik ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Growth Factors ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Proinflammatory Cytokines ◽  
Ulcer Healing ◽  
Diabetic Rats ◽  
Gastric Ulcer Healing

Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines

2003 ◽  
Vol 481 (2-3) ◽  
pp. 249-260 ◽  
Author(s):  
Igor A. Harsch ◽  
Tomasz Brzozowski ◽  
Karolina Bazela ◽  
Stanislaw J. Konturek ◽  
Vitaly Kukharsky ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Growth Factors ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Proinflammatory Cytokines ◽  
Ulcer Healing ◽  
Diabetic Rats ◽  
Gastric Ulcer Healing

Stimulation of gastric ulcer healing by heat shock protein 70

2011 ◽  
Vol 82 (7) ◽  
pp. 728-736 ◽  
Author(s):  
Tomoaki Ishihara ◽  
Shintaro Suemasu ◽  
Teita Asano ◽  
Ken-ichiro Tanaka ◽  
Tohru Mizushima
Keyword(s):  
Gastric Ulcer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Ulcer Healing ◽  
Heat Shock Protein 70 ◽  
Gastric Ulcer Healing ◽  
Stimulation Of

Heat Shock Protein A4 Controls Cell Migration and Gastric Ulcer Healing

2015 ◽  
Vol 60 (4) ◽  
pp. 850-857 ◽  
Author(s):  
Toshiharu Sakurai ◽  
Hiroshi Kashida ◽  
Satoru Hagiwara ◽  
Naoshi Nishida ◽  
Tomohiro Watanabe ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Cell Migration ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing

scholarly journals Age-Related Changes in the Expression of Heat Shock Protein 70 and 90 on the Gastric Mucosa During Gastric Ulcer Healing

2018 ◽  
Vol 6 (5) ◽  
pp. 01 ◽  
Author(s):  
Ajayi Ayodeji Folorunsho ◽  
Aniviye Blessing Oluwafunke ◽  
Kehinde Busuyi David ◽  
Akintola Adebola Olayemi
Keyword(s):  
Gastric Ulcer ◽  
Heat Shock ◽  
Gastric Mucosa ◽  
Heat Shock Protein ◽  
Ulcer Healing ◽  
Heat Shock Protein 70 ◽  
Gastric Ulcer Healing ◽  
Age Related ◽  
Age Related Changes

Role of nuclear factor-κB in gastric ulcer healing in rats

2001 ◽  
Vol 280 (6) ◽  
pp. G1296-G1304 ◽  
Author(s):  
Satoru Takahashi ◽  
Takuya Fujita ◽  
Akira Yamamoto
Keyword(s):  
Gastric Ulcer ◽  
Mrna Expression ◽  
Ulcer Healing ◽  
Nuclear Factor Κb ◽  
Normal Mucosa ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Nuclear Factor ◽  
Gastric Ulcer Healing

We investigated the role of nuclear factor-κB (NF-κB) in gastric ulcer healing in rats. NF-κB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing. NF-κB activation was observed in fibroblasts, monocytes/macrophages, and neutrophils. Treatment of gastric fibroblasts, isolated from the ulcer base, with interleukin-1β activated NF-κB and the subsequently induced cyclooxygenase-2 and cytokine-induced neutrophil chemoattractant-1 (CINC-1) mRNA expression. Inhibition of activated NF-κB action resulted in suppression of both their mRNA expression and increases in PGE2 and CINC-1 levels induced by interleukin-1β. Persistent prevention of NF-κB activation caused an impairment of ulcer healing in rats. Gene expression of interleukin-1β, CINC-1, cyclooxygenase-2, and inducible nitric oxide synthase in ulcerated tissue had been inhibited before the delay in ulcer healing became manifest. The increased levels of cyclooxygenase-2 protein and PGE2 production were also reduced. These results demonstrate that NF-κB, activated in ulcerated tissue, might upregulate the expression of healing-promoting factors responsible for gastric ulcer healing in rats.

Sign in / Sign up

Export Citation Format

Share Document