Objective:
The need of today’s research is to develop successful and reliable diabetic animal
models for understanding the disease susceptibility and pathogenesis. Enormous success of animal
models had already been acclaimed for identifying key genetic and environmental factors like Idd loci
and effects of microorganisms including the gut microbiota. Furthermore, animal models had also
helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of a
quite success, we have acknowledged that many of the discovered immunotherapies are working on
animals and did not have a significant impact on human. Number of animal models were developed in
the past to accelerate drug discovery pipeline. However, due to poor initial screening and assessment
on inequivalent animal models, the percentage of drug candidates who succeeded during clinical trials
was very low. Therefore, it is essential to bridge this gap between pre-clinical research and clinical trial
by validating the existing animal models for consistency.
Results and Conclusion:
In this review, we have discussed and evaluated the significance of animal
models on behalf of published data on PUBMED. Amongst the most popular diabetic animal models,
we have selected six animal models (e.g. BioBreeding rat, “LEW IDDM rat”, “Nonobese Diabetic
(NOD) mouse”, “STZ RAT”, “LEPR Mouse” and “Zucker Diabetic Fatty (ZDF) rat” and ranked them
as per their published literature on PUBMED. Moreover, the vision and brief imagination for developing
an advanced and robust diabetic model of 21st century was discussed with the theme of one miceone
human concept including organs-on-chips.
The BioBreeding rat diabetes model is infected with Ljungan virus