scholarly journals The Dynamic Change of PTEN Expression During Fibrogenesis and Reversal of Rat Liver Fibrosis Induced by CCl4 and Its Relation With the Activation and Proliferation of Hepatic Stellate Cells (HSC) In Vivo

2011 ◽  
Vol 140 (5) ◽  
pp. S-981
Author(s):  
Xiaolan Zhang ◽  
Libo Zheng ◽  
Junyan An ◽  
Jian Guo ◽  
Jingshu Han ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Liver ◽  
Hepatic Stellate Cells ◽  
Dynamic Change ◽  
Stellate Cells ◽  
Pten Expression ◽  
Rat Liver Fibrosis

scholarly journals A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Yang Xu ◽  
Zhangxiao Peng ◽  
Weidan Ji ◽  
Xiang Li ◽  
Xuejing Lin ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Liver ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Critical Event ◽  
Pharmacological Activities ◽  
Fibrosis Progression ◽  
Collagen Iii ◽  
Rat Liver Fibrosis ◽  
Low Toxicity

Activation of hepatic stellate cells (HSCs) is a critical event in process of hepatic fibrogenesis and cirrhosis. Matrine, the active ingredient ofSophora, had been used for clinical treatment of acute/chronic liver disease. However, its potency was low. We prepared a high potency and low toxicity matrine derivate, WM130 (C30N4H40SO5F), which exhibited better pharmacological activities on antihepatic fibrosis. This study demonstrated that WM130 results in a decreased proliferative activity of HSC-T6 cells, with the half inhibitory concentration (IC50) of 68 μM. WM130 can inhibit the migration and induce apoptosis in HSC-T6 cells at both concentrations of 68 μM (IC50) and 34 μM (half IC50). The expression ofα-SMA, Collagen I, Collagen III, and TGF-β1 could be downregulated, and the protein phosphorylation levels of EGFR, AKT, ERK, Smad, and Raf (p-EGFR, p-AKT, p-ERK, p-Smad, and p-Raf) were also decreased by WM130. On the DMN-induced rat liver fibrosis model, WM130 can effectively reduce the TGF-β1, AKT,α-SMA, and p-ERK levels, decrease the extracellular matrix (ECM) formation, and inhibit rat liver fibrosis progression. In conclusion, this study demonstrated that WM130 can significantly inhibit the activation of HSC-T6 cells and block the rat liver fibrosis progression by inducing apoptosis, suppressing the deposition of ECM, and inhibiting TGF-β/Smad and Ras/ERK pathways.

The anti-fibrotic effect of Aramchol on rat liver fibrosis induced by TAA and in vitro on primary hepatic stellate cells

2018 ◽  
Vol 68 ◽  
pp. S407
Author(s):  
R. Golan-Gerstl ◽  
M. Valitsky ◽  
R. Oren ◽  
E. Brazowski ◽  
L. Hayardeni ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Liver ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Rat Liver Fibrosis

scholarly journals Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells

2001 ◽  
Vol 35 (4) ◽  
pp. 474-481 ◽  
Author(s):  
Toru Murata ◽  
Shigeki Arii ◽  
Toshio Nakamura ◽  
Akira Mori ◽  
Toshimi Kaido ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Rat Liver ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Inhibitory Effect ◽  
Rock Inhibitor ◽  
Rat Liver Fibrosis
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