Su1777 Risk of Serious Upper Gastrointestinal (UGI) Complications With use of Non-Selective (NS) NSAIDs for at Least 4 Weeks Among Patients With a History of Peptic Ulcer (PU) or PU Complications: A Series of Systematic Reviews and Meta-Analyses

2012 ◽  
Vol 142 (5) ◽  
pp. S-501
Author(s):  
Grigorios I. Leontiadis ◽  
Yuhong Yuan ◽  
Frances Tse ◽  
Richard H. Hunt ◽  
Paul Moayyedi
Keyword(s):  
Peptic Ulcer ◽  
Systematic Reviews ◽  
History Of ◽  
Meta Analyses ◽  
Upper Gastrointestinal

scholarly journals Repeat Upper Gastrointestinal Endoscopy in Patients with Functional Dyspepsia: Yield, Findings, and Predictors of Positive Findings

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Supot Pongprasobchai ◽  
Natta Asanaleykha ◽  
Pongchirat Tantayakom
Keyword(s):  
Peptic Ulcer ◽  
Functional Dyspepsia ◽  
Reflux Esophagitis ◽  
Gastrointestinal Endoscopy ◽  
Multivariate Analyses ◽  
Upper Gastrointestinal Endoscopy ◽  
Erosive Gastritis ◽  
History Of ◽  
Alarm Features ◽  
Upper Gastrointestinal

Background. No guideline on repeat esophagogastroduodenoscopy (EGD) in functional dyspepsia (FD) exists. This study aimed to define yield, findings, and predictors of positive findings on repeat EGD in FD.Methods. FD patients who underwent at least 2 EGDs during October 2005 to November 2011 were enrolled and reviewed. Yield and findings were analyzed and univariate and multivariate analyses were performed to identify predictors of positive repeat EGD.Results. The median time to repeat EGD was 34 months. Among 146 patients, 115 patients (79%) had negative and 31 (21%) had positive repeat EGD, including erosive gastritis (13.0%), peptic ulcer (7.5%), reflux esophagitis (1.4%), and Barrett’s esophagus (0.7%). Four independent predictors of positive repeat EGD were smoking (HR 3.88, 95% CI 1.31–11.51,P=0.015), hypertension (HR 2.96, 95% CI 1.38–6.36,P=0.050), history of malignancies (HR 3.65, 95% CI 1.16–11.46,P=0.027), and antiplatelets or NSAIDs used within 4 weeks (HR 4.10, 95% CI 1.13–14.90,P=0.032), while alarm features or failure to treatment did not predict positive repeat EGD.  Conclusion. Yield of repeat EGD in FD was substantially low, all findings were acid-related disorders, and there was no malignancy. Smoking, hypertension, history of malignancies, and antiplatelets/NSAIDs use associated with positive repeat EGD.

Contributions of Meta-analysis to Conservation and Management

2013 ◽  
Author(s):  
Isabelle M. Côté ◽  
Gavin B. Stewart
Keyword(s):  
Decision Making ◽  
Systematic Reviews ◽  
Large Scale ◽  
Meta Analysis ◽  
Conservation Policy ◽  
Small Scale ◽  
Management Interventions ◽  
History Of ◽  
Meta Analyses ◽  
Conservation And Management

This chapter looks back through the relatively short history of meta-analyses and systematic reviews of conservation interest and highlights four areas to which these methods have contributed significantly. These include challenging conventional wisdom, measuring effectiveness of management interventions, replacing large-scale monitoring with small-scale surveys, and identifying gaps in knowledge. The chapter shows that meta-analyses and systematic reviews have contributed to answering a number of important applied questions. However, although these answers often have clear implications for conservation policy and legislation, they currently remain the focus of primarily academic interest. Given a little more time, evidence bases that are collated using systematic reviews, particularly in association with meta-analysis, are expected to increasingly influence decision making in the environmental sector, just as they have in medical fields.

scholarly journals Centralization of Highly Complex Low-Volume Procedures in Upper Gastrointestinal Surgery. A Summary of Systematic Reviews and Meta-Analyses

2012 ◽  
Vol 29 (5) ◽  
pp. 374-383 ◽  
Author(s):  
Johanna A.M.G. Tol ◽  
Thomas M. van Gulik ◽  
Olivier R.C. Busch ◽  
Dirk J. Gouma
Keyword(s):  
Systematic Reviews ◽  
Gastrointestinal Surgery ◽  
Low Volume ◽  
Meta Analyses ◽  
Upper Gastrointestinal

scholarly journals Endoscopic profile and clinical outcome of patients presenting with upper gastrointestinal bleeding

2020 ◽  
Vol 7 (9) ◽  
pp. 1355
Author(s):  
Ashish Kumar ◽  
Umang Kasturi ◽  
Amritpal Singh ◽  
Dharamjit Kaur
Keyword(s):  
Peptic Ulcer ◽  
Portal Hypertension ◽  
Liver Disease ◽  
Clinical Outcome ◽  
Gastrointestinal Bleeding ◽  
Peptic Ulcer Disease ◽  
Upper Gastrointestinal Bleeding ◽  
Ulcer Disease ◽  
History Of ◽  
Upper Gastrointestinal

Background: Acute upper gastrointestinal bleeding is a common medical emergency with significant mortality. The aim of the present study is to study endoscopic profile and clinical outcome of patients presenting with upper gastrointestinal bleeding in this region. Methods: This prospective observational study carried out on 100 patients admitted with upper gastrointestinal bleeding. All patients included in study underwent upper gastrointestinal endoscopy after initial evaluation and stabilization.  Status of study group patients was noted at discharge. Patients were telephonically contacted at day 15 and were asked about rebleed, readmission for gastrointestinal bleed or death of the patient.Results: The mean age of patients was 48.98 ±14.50 years with male to female ratio of 2.57:1. The most common lesions causing UGI bleed were related to portal hypertension (esophageal and gastric varices) and were seen in 67% of patients. Non portal hypertensive lesions causing UGI bleed (peptic and other lesions) were seen in 46% patients. Twenty six percent patients had combination of lesions while endoscopy was normal in 3% patients. Rebleeding within 15 days was seen in 11 patients out of whom 3 died during same admission. Out of other 8 patients with rebleed, readmission was seen in 6 patients while 2 patients had minor bleed. We found no correlation of mortality and rebleed with factors like age, history of liver disease, diabetes, NSAIDs use, peptic ulcer disease and presence of cirrhosis. However the correlation between rebleed and death was found to be statistically significant.Conclusions: Portal hypertension is the most common cause of upper gastrointestinal bleeding in this region. There is strong correlation between rebleeding and death. However there is no correlation between age, history of liver disease, diabetes, NSAIDs use, peptic ulcer disease and presence of cirrhosis with rebleed or mortality.

Hotspots in Psychology – 2020 Edition

2020 ◽  
Vol 228 (1) ◽  
pp. 1-2
Author(s):  
Michael Bošnjak ◽  
Nadine Wedderhoff
Keyword(s):  
Systematic Reviews ◽  
Research Synthesis ◽  
Synthesis Methods ◽  
Common Denominator ◽  
The Common ◽  
Meta Analyses

Abstract. This editorial gives a brief introduction to the six articles included in the fourth “Hotspots in Psychology” of the Zeitschrift für Psychologie. The format is devoted to systematic reviews and meta-analyses in research-active fields that have generated a considerable number of primary studies. The common denominator is the research synthesis nature of the included articles, and not a specific psychological topic or theme that all articles have to address. Moreover, methodological advances in research synthesis methods relevant for any subfield of psychology are being addressed. Comprehensive supplemental material to the articles can be found in PsychArchives ( https://www.psycharchives.org ).

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