Su1955 Alpha Melanocyte-Stimulating Hormone (MSH), Melanin-Concentrating Hormone (MCH), and Obestatin are Associated With Hepatic Inflammation in Morbidly Obese Non-Alcoholic Fatty Liver Disease (NAFLD) Patients

2012 ◽  
Vol 142 (5) ◽  
pp. S-545
Author(s):  
Ancha Baranova ◽  
Massih Abawi ◽  
Lei Wang ◽  
Zachary Goodman ◽  
Vikas Chandhoke ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Hepatic Inflammation ◽  
Alcoholic Fatty Liver ◽  
Melanocyte Stimulating Hormone ◽  
Melanin Concentrating Hormone ◽  
Alcoholic Fatty Liver Disease ◽  
Stimulating Hormone

scholarly journals Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mihiri Goonetilleke ◽  
Nathan Kuk ◽  
Jeanne Correia ◽  
Alex Hodge ◽  
Gregory Moore ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Epithelial Cells ◽  
Fatty Liver ◽  
Progenitor Cells ◽  
Fatty Liver Disease ◽  
Hepatic Inflammation ◽  
Alcoholic Fatty Liver ◽  
And Oxidative Stress ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease is the most common liver disease globally and in its inflammatory form, non-alcoholic steatohepatitis (NASH), can progress to cirrhosis and hepatocellular carcinoma (HCC). Currently, patient education and lifestyle changes are the major tools to prevent the continued progression of NASH. Emerging therapies in NASH target known pathological processes involved in the progression of the disease including inflammation, fibrosis, oxidative stress and hepatocyte apoptosis. Human amniotic epithelial cells (hAECs) were previously shown to be beneficial in experimental models of chronic liver injury, reducing hepatic inflammation and fibrosis. Previous studies have shown that liver progenitor cells (LPCs) response plays a significant role in the development of fibrosis and HCC in mouse models of fatty liver disease. In this study, we examined the effect hAECs have on the LPC response and hepatic oxidative stress in an experimental model of NASH. Methods Experimental NASH was induced in C57BL/6 J male mice using a high-fat, high fructose diet for 42 weeks. Mice received either a single intraperitoneal injection of 2 × 106 hAECs at week 34 or an additional hAEC dose at week 38. Changes to the LPC response and oxidative stress regulators were measured. Results hAEC administration significantly reduced the expansion of LPCs and their mitogens, IL-6, IFNγ and TWEAK. hAEC administration also reduced neutrophil infiltration and myeloperoxidase production with a concurrent increase in heme oxygenase-1 production. These observations were accompanied by a significant increase in total levels of anti-fibrotic IFNβ in mice treated with a single dose of hAECs, which appeared to be independent of c-GAS-STING activation. Conclusions Expansion of liver progenitor cells, hepatic inflammation and oxidative stress associated with experimental NASH were attenuated by hAEC administration. Given that repeated doses did not significantly increase efficacy, future studies assessing the impact of dose escalation and/or timing of dose may provide insights into clinical translation.

Non-alcoholic fatty liver disease is common in morbidly obese individuals with normal aminotransferases

2003 ◽  
Vol 124 (4) ◽  
pp. A745
Author(s):  
Raphael B. Merriman ◽  
Shiobhan Weston ◽  
Karen Gagetelos ◽  
Marco Patti ◽  
Linda Ferrell ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Association between Thyroid-Stimulating Hormone Levels and Non-Alcoholic Fatty Liver Disease Is Not Independent from Metabolic Syndrome Criteria

2018 ◽  
Vol 7 (6) ◽  
pp. 302-307 ◽  
Author(s):  
Carolina Castro Porto Silva Janovsky ◽  
Fernando H. Cesena ◽  
Viviane Arevalo Tabone Valente ◽  
Raquel Dilguerian de Oliveira Conceição ◽  
Raul D. Santos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Thyroid Stimulating Hormone ◽  
Alcoholic Fatty Liver ◽  
Hormone Levels ◽  
Alcoholic Fatty Liver Disease ◽  
Stimulating Hormone

Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Morbidly Obese South Indian Patients Undergoing Bariatric Surgery

2015 ◽  
Vol 25 (11) ◽  
pp. 2078-2087 ◽  
Author(s):  
Palanivelu Praveenraj ◽  
Rachel M. Gomes ◽  
Saravana Kumar ◽  
Purushothaman Karthikeyan ◽  
Annapoorni Shankar ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Alcoholic Fatty Liver ◽  
Indian Patients ◽  
South Indian ◽  
Alcoholic Fatty Liver Disease

500 Losartan Improves Hepatic Inflammation in Children With Non-Alcoholic Fatty Liver Disease

2016 ◽  
Vol 150 (4) ◽  
pp. S1036 ◽  
Author(s):  
Miriam Vos ◽  
Ran Jin ◽  
Jean Welsh ◽  
Juna Konomi ◽  
Saul J. Karpen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hepatic Inflammation ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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