scholarly journals Su1532 – Complications of Suprahepatic Inferior Caval Vein Obstruction in Rats. Pentadecapeptide Bpc 157 Induces Inferior-Superior Caval Vein Shunt Through Azygos Vein and Counteracts Venous Thrombosis and Arrhythmias

2019 ◽  
Vol 156 (6) ◽  
pp. S-563-S-564
Author(s):  
Slaven Gojkovic ◽  
Ivan Krezic ◽  
Helena Zizek ◽  
Dominik Malekinusic ◽  
Tajana Durasin ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Azygos Vein ◽  
Caval Vein ◽  
Bpc 157 ◽  
Superior Caval Vein ◽  
Inferior Caval Vein ◽  
Pentadecapeptide Bpc 157

Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing

2018 ◽  
Vol 24 (18) ◽  
pp. 1990-2001 ◽  
Author(s):  
Predrag Sikiric ◽  
Rudolf Rucman ◽  
Branko Turkovic ◽  
Marko Sever ◽  
Robert Klicek ◽  
...  
Keyword(s):  
Large Scale ◽  
Venous Occlusion ◽  
Cell Protection ◽  
Caval Vein ◽  
Bpc 157 ◽  
Beneficial Effects ◽  
Mucosal Integrity ◽  
Inferior Caval Vein ◽  
Cytoprotective Agent ◽  
Pentadecapeptide Bpc 157

Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti-ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy. However, having managed these two points, stomach cell protection and endothelium protection, either one or together, even much more than standard cytoprotective agents do, BPC 157 employed large scale of its beneficial effects seen in various organs. Providing endothelium protection, BPC 157 was shown to prevent formation and reverse established thrombosis in anastomosed abdominal aorta as well as venous thrombosis after inferior caval vein occlusion, and attenuate bleeding prolongation and thrombocytopenia after amputation, without or with anticoagulants, or venous occlusion, and finally counteract effect of L-NAME and/or L- arginine. Now, with BPC 157 application, we reveal the third most important part of the cytoprotection concept: with the stomach cell and endothelium protection to recover mucosal integrity, BPC 157 as prototype cytoprotective agent should also control blood vessel function, depending upon injury, perforated defect or vessel obstruction. After a perforated injury (i.e., stomach), BPC 157 therapy activates blood vessels “running” towards defect. After obstruction (i.e., inferior caval vein), BPC 157 activates vessels “running” towards bypassing defect, collaterals functioning. Reestablished blood flow, and largely reversed injurious course may practically implement the cytoprotection concept.

Intracardiac or extracardiac conduit modification of the Fontan procedure in hearts with univentricular atrioventricular connection and left superior caval vein draining to coronary sinus

1997 ◽  
Vol 7 (2) ◽  
pp. 215-219
Author(s):  
Jacques A.M. van Son ◽  
Volkmar Falk ◽  
Friedrich W. Mohr
Keyword(s):  
Coronary Sinus ◽  
Venous Blood ◽  
Azygos Vein ◽  
Caval Vein ◽  
Arterial Circulation ◽  
Superior Caval Vein ◽  
Inferior Caval Vein ◽  
Extracardiac Conduit ◽  
Hepatic Venous Blood ◽  
Pulmonary Arterial

AbstractIn 3 patients with isomeric morphologically left atrial appendages, univentricular atrioventricular connection, concordant ventriculoarterial connections, bilateral superior caval veins, with the left one draining via the coronary sinus, together with absence of any communicating vein, interruption of inferior caval vein with drainage via a right-sided (n=2) or left-sided (n=l) azygos vein, the hepatic venous blood was rerouted via the large coronary sinus into the pulmonary arterial circulation. In a fourth patient with similar pathology, having interruption of the left-sided inferior caval vein with drainage to the left-sided superior caval vein via a left-sided azygos vein and a large communicating vein, the pathway from the left superior caval vein to the coronary sinus was correspondingly small. An extracardiac conduit was therefore constructed between the hepatic veins and the left pulmonary artery so as to reroute the hepatic venous blood into the pulmonary arterial circulation. At a mean follow-up of 8.5 months, all patients are clinically well and none of them have developed pulmonary arteriovenous malformations. To avoid the latter complication in Fontan physiology, especially in the setting of an interrupted inferior caval vein with drainage via the azygos vein, we believe that it is preferable to reroute the hepatic venous blood into the pulmonary circulation.

Su1474 - Stable Gastric Pentadecapeptide Bpc 157 Therapy for Subdiaphragmatic Occlusion of the Suprahepatic Inferior Caval Vein in Rats

2018 ◽  
Vol 154 (6) ◽  
pp. S-532
Author(s):  
Slaven Gojkovic ◽  
Helena Zizek ◽  
Ivan Krezic ◽  
Dominik Malekinusic ◽  
Borna Vrdoljak ◽  
...  
Keyword(s):  
Caval Vein ◽  
Bpc 157 ◽  
Inferior Caval Vein ◽  
Pentadecapeptide Bpc 157

scholarly journals Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats

2020 ◽  
Vol 11 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Slaven Gojkovic ◽  
Ivan Krezic ◽  
Borna Vrdoljak ◽  
Dominik Malekinusic ◽  
Ivan Barisic ◽  
...  
Keyword(s):  
Budd Chiari Syndrome ◽  
Caval Vein ◽  
Bpc 157 ◽  
Inferior Caval Vein ◽  
Chiari Syndrome ◽  
Pentadecapeptide Bpc 157

Transcatheter therapy of anomalous systemic venous drainage

2017 ◽  
Vol 28 (3) ◽  
pp. 502-506
Author(s):  
Shahnawaz M. Amdani ◽  
Thomas J. Forbes ◽  
Daisuke Kobayashi
Keyword(s):  
Left Atrium ◽  
Pulmonary Vein ◽  
Pulmonary Veins ◽  
Three Dimensional ◽  
Venous Drainage ◽  
Azygos Vein ◽  
Caval Vein ◽  
Superior Caval Vein ◽  
Inferior Caval Vein ◽  
The Right

AbstractAnomalous drainage of the right superior caval vein into the left atrium is a rare congenital anomaly that causes cyanosis and occult infection owing to right-to-left shunting. Transcatheter management of this anomaly is unique and rarely reported. We report a 32-year-old man with a history of brain abscess, who was diagnosed with an anomalous right superior caval vein draining to the left atrium; right upper pulmonary vein and right middle pulmonary vein draining into the inferior portion of the right superior caval vein; and a left superior caval vein draining into the right atrium through the coronary sinus without a bridging vein. Pre-procedural planning was guided by three-dimensional printed model. The right superior caval vein was occluded with a 16-mm Amplatzer muscular Ventricular Septal Defect occluder inferior to the azygous vein, but superior to the entries of right upper and middle pulmonary veins. This diverted the right superior caval vein flow to the inferior caval vein system through the azygos vein in a retrograde manner and allowed the right upper pulmonary vein and right middle pulmonary vein flow to drain into the left atrium normally, achieving exclusion of right-to-left shunting and allowing normal drainage of pulmonary veins into the left atrium. At the 6-month follow-up, his saturation improved from 93 to 97% with no symptoms of superior caval vein syndrome.

Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157

2018 ◽  
Vol 106 ◽  
pp. 54-66 ◽  
Author(s):  
Jakša Vukojević ◽  
Marko Siroglavić ◽  
Katarina Kašnik ◽  
Tamara Kralj ◽  
Duje Stanćić ◽  
...  
Keyword(s):  
Caval Vein ◽  
Bpc 157 ◽  
Inferior Caval Vein ◽  
Pentadecapeptide Bpc 157

scholarly journals Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Marijan Tepes ◽  
Slaven Gojkovic ◽  
Ivan Krezic ◽  
Helena Zizek ◽  
Hrvoje Vranes ◽  
...  
Keyword(s):  
Compartment Syndrome ◽  
Abdominal Compartment Syndrome ◽  
Azygos Vein ◽  
Abdominal Pressure ◽  
Bpc 157 ◽  
Anesthetized Rats ◽  
Abdominal Hypertension ◽  
Major Vessel ◽  
Pentadecapeptide Bpc 157 ◽  
Abdominal Compartment

Recently, the stable gastric pentadecapeptide BPC 157 was shown to counteract major vessel occlusion syndromes, i.e., peripheral and/or central occlusion, while activating particular collateral pathways. We induced abdominal compartment syndrome (intra-abdominal pressure in thiopental-anesthetized rats at 25 mmHg (60 min), 30 mmHg (30 min), 40 mmHg (30 min), and 50 mmHg (15 min) and in esketamine-anesthetized rats (25 mmHg for 120 min)) as a model of multiple occlusion syndrome. By improving the function of the venous system with BPC 157, we reversed the chain of harmful events. Rats with intra-abdominal hypertension (grade III, grade IV) received BPC 157 (10 µg or 10 ng/kg sc) or saline (5 ml) after 10 min. BPC 157 administration recovered the azygos vein via the inferior–superior caval vein rescue pathway. Additionally, intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension were reduced, as were the grossly congested stomach and major hemorrhagic lesions, brain swelling, venous and arterial thrombosis, congested inferior caval and superior mesenteric veins, and collapsed azygos vein; thus, the failed collateral pathway was fully recovered. Severe ECG disturbances (i.e., severe bradycardia and ST-elevation until asystole) were also reversed. Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited. In the liver, BPC 157 reduced congestion and severe sinusoid enlargement. In the lung, a normal presentation was observed, with no alveolar membrane focal thickening and no lung congestion or edema, and severe intra-alveolar hemorrhage was absent. Moreover, severe heart congestion, subendocardial infarction, renal hemorrhage, brain edema, hemorrhage, and neural damage were prevented. In conclusion, BPC 157 cured primary abdominal compartment syndrome.

Hybrid closure of a large atrial septal defect using Occlutech Flex II septal occluder in a patient with interrupted inferior caval vein

2020 ◽  
Vol 30 (6) ◽  
pp. 880-882
Author(s):  
Amjad Bani Hani ◽  
Mai Abdullattif ◽  
Iyad AL-Ammouri
Keyword(s):  
Cardiopulmonary Bypass ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Caval Vein ◽  
Superior Caval Vein ◽  
Inferior Caval Vein ◽  
Thoracotomy Incision

AbstractWe present a case of a 31-year-old male with a large atrial septal defect, who was found to have interrupted inferior caval vein with azygous continuation to the superior caval vein, which precluded transcutaneous closure by device. The defect was successfully closed with a 33 mm Occlutech Figula septal occluder using a sub-mammary small thoracotomy incision and per-atrial approach without using cardiopulmonary bypass. The patient was discharged home after 48 hours of procedure.

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