Sa1343 CLASSIFICATION OF AUTOIMMUNE GASTRITIS BASED ON THE STATUS OF POLYGLANDULAR POLYGLANDULAR AUTOIMMUNE SYNDROME

Background: CTLA-4 and PD-1L are novel immune checkpoint targets for cancer treatment with specific side effects such as autoimmune diseases. Less frequently, the presence of several autoimmune diseases in the same patient has been described. In this communication, we illustrate the case of a 45-year-old patient with a previous diagnosis of advanced cancer that, after starting treatment with this immunotherapy, developed in the following months autoimmune diabetes, lymphocytic hypophysitis, and a Hashimoto thyroiditis in an abrupt and intense manner that would correspond to an autoimmune polyglandular disease. Discussion: The activation of autoimmunity and associated diseases is increasing in parallel with augmented indication of these immunotherapeutic treatments in cancer patients. A closer follow-up of these patients could be necessary for an optimal approach to this type of pathology. Conclusions: Different autoimmune diseases can converge in the same patient when immunotherapy for cancer is indicated to boost immune response against tumor, caused by altering immune tolerance.

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Polyglandular Autoimmune Syndrome Associated with Pigmented Basal Cell Carcinoma

The Journal of Dermatology ◽

10.1111/j.1346-8138.2005.tb00899.x ◽

2005 ◽

Vol 32 (12) ◽

pp. 1044-1047 ◽

Cited By ~ 3

Author(s):

Michael Sand ◽

Falk Georges Bechara ◽

Daniel Sand ◽

Georg Moussa ◽

Markus Stücker ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Polyglandular Autoimmune Syndrome ◽

Autoimmune Syndrome

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Autoantibodies cytotoxic to parathyroid cells in polyglandular autoimmune syndrome type 1 (PGAI)

Bone ◽

10.1016/8756-3282(86)90348-0 ◽

1986 ◽

Vol 7 (5) ◽

pp. 412-413

Author(s):

M.L. Brandi ◽

L.A. Fitzpatrick ◽

G.D. Aurbach

Keyword(s):

Syndrome Type ◽

Polyglandular Autoimmune Syndrome ◽

Autoimmune Syndrome ◽

Polyglandular Autoimmune Syndrome Type

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Max Scheler’s Pluralistic Conception of Knowledge

Dialogue and Universalism ◽

10.5840/du202131supplement38 ◽

2021 ◽

Vol 31 (9999) ◽

pp. 83-94

Author(s):

Stanisław Czerniak ◽

Keyword(s):

Philosophy Of Science ◽

Historical Context ◽

Theory Of Knowledge ◽

Scientific Communities ◽

Late Work ◽

Types Of Knowledge ◽

Knowledge Types ◽

The Status ◽

Philosophy Of Knowledge

This article aims to reconstruct Max Scheler’s conception of three types of knowledge, outlined in his late work Philosophical Perspectives (1928). Scheler distinguished three kinds of knowledge: empirical, used to exercise control over nature, eidetic (essential) and metaphysical. The author reviews the epistemological criteria that underlie this distinction, and its functionalistic assumptions. In the article’s polemic part he accuses Scheler of a) crypto-dualism in his theory of knowledge, which draws insufficient distinctions between metaphysical and eidetic knowledge; b) totally omitting the status of the humanities in his classification of knowledge types; c) consistently developing a philosophy of knowledge without resort to the research tools offered by the philosophy of science, which takes such analyses out of their social and historical context (i.e. how knowledge is created in today’s scientific communities).

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